Translational research in the cardiovascular field is hampered by the unavailability of
cardiac models that can recapitulate organ-level physiology of the myocardium. Outside the …

Surface morphology, in addition to hydrophobic and electrostatic effects, can alter how
proteins interact with solid surfaces. Understanding the heterogeneous dynamics of protein …

The intercalated disc (ICD) is a unique membrane structure that is indispensable to normal
heart function, yet its structural organization is not completely understood. Previously, we …

In the current study we examined several proteomic-and RNA-Seq-based datasets of
cardiac-enriched, cell-surface and membrane-associated proteins in human fetal and …

Obesity, type 2 diabetes, and heart disease are linked to an unhealthy diet. Sarco (endo)
plasmic reticulum calcium (Ca2+) ATPase 2a (SERCA2a) controls cardiac function by …

Cell-based models that mimic in vivo heart physiology are poised to make significant
advances in cardiac disease modeling and drug discovery. In these systems, cardiomyocyte …

We are inviting submissions of articles on the role of mechanobiology in health and disease
with the aim of publishing high quality research devoted to advance our understanding of …

Abstract Discoidin domain receptor 1 (DDR1) is a collagen-binding receptor tyrosine kinase
that regulates cellular growth, migration, and cell-matrix interactions. However, the roles of …

Over the last two decades the pharmaceutical industry has been dynamic, moving away
from traditional small molecules towards protein-based drugs, also called biologics. 1 Figure …

Over the last decade the pharmaceutical industry has been experiencing a scientific
revolution, resulting in more biological-based therapeutics, also called biologics. Biologics …