Over the past years, the phenotypic and functional boundaries distinguishing the main cell
subsets of the immune system have become increasingly blurred. In this respect, CD56 (also …

Untreated HIV-1 infection typically progresses to AIDS within 10 years, but less than 1% of
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …

Gamma-delta (γδ) T cells recognize antigens in a major histocompatibility complex (MHC)
independent and have cytotoxic capability. Human immunodeficiency virus (HIV) infection …

γδ T cells are non-conventional lymphocytes which show several properties of innate
immune cells. They present a limited TCR repertoire and circulate as cells with a pre …

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset,
recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous …

T lymphocytes respond to a broad array of pathogens with the combinatorial diversity of the
T cell receptor (TCR). This adaptive response is possible because of the unique structure of …

Recent advances in γδ T cell biology have focused on the unique attributes of these cells
and their role in regulating innate and adaptive immunity, promoting tissue homeostasis …

The emergence of viruses with pandemic potential such as the SARS-CoV-2 coronavirus
causing COVID-19 poses a global health challenge. There is remarkable progress in …

Human immunodeficiency virus (HIV) type 1 dysregulates γδ T cells as part of an immune
evasion mechanism. Nearly three decades of research defined the effects of HIV on γδ T …

HIV infection is associated with a rapid and sustained inversion of the Vδ1: Vδ2 T‐cell ratio
in peripheral blood. Studies of antiretroviral therapy (ART)‐treated cohorts suggest that ART …