Multicomponent reactions (MCRs) are generally defined as reactions where more than two
staring materials react to form a product, incorporating essentially all of the atoms of the …

Asymmetric multicomponent reactions involve the preparation of chiral compounds by the
reaction of three or more reagents added simultaneously. This kind of addition and reaction …

Sustainable or green chemistry has established firm ground providing essential design
criteria for the development of efficient chemical syntheses of complex, high added value …

The Ugi-4CR is by far one of the most successful multicomponent reactions leading to high
structural diversity and molecular complexity. However, the reaction mostly affords a linear …

In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has
received much attention. This because they have shown in many cases enhanced …

Abstract Unter der asymmetrischen Mehrkomponenten‐Reaktion versteht man die Synthese
von chiralen Verbindungen aus drei oder mehr gleichzeitig zusammengegebenen …

A four-component coupling process involving sequential reactions of aldehydes, primary
amines, acid chlorides, and nucleophiles has been developed to prepare multifunctional …

This review details a now established area within the isonitrile multi-component reaction
(IMCR) field of study, namely employing bi-functional reagents in the Ugi reaction for the …

Linear amides 4, prepared in one step by the Ugi four-component reaction, were converted
to 3, 4-dihydroquinoxalin-3-ones (5) or to 2-(2-oxoindolin-1-yl) acetamides (6) dependent on …

Herein we report a concise protocol for the diastereoselective synthesis of novel bridged
bicyclic lactams from commercially available components by the sequence of Ugi, ring …