Scorpion venom components as potential candidates for drug development
E Ortiz, GB Gurrola, EF Schwartz, LD Possani - Toxicon, 2015 - Elsevier
Scorpions are well known for their dangerous stings that can result in severe consequences
for human beings, including death. Neurotoxins present in their venoms are responsible for …
for human beings, including death. Neurotoxins present in their venoms are responsible for …
The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
A global accounting of medically significant scorpions: Epidemiology, major toxins, and comparative resources in harmless counterparts
Scorpions are an ancient and diverse venomous lineage, with over 2200 currently
recognized species. Only a small fraction of scorpion species are considered harmful to …
recognized species. Only a small fraction of scorpion species are considered harmful to …
Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality
Tityus serrulatus sting causes thousands of deaths annually worldwide. T. serrulatus-
envenomed victims exhibit local or systemic reaction that culminates in pulmonary oedema …
envenomed victims exhibit local or systemic reaction that culminates in pulmonary oedema …
Tityus serrulatus venom–a lethal cocktail
Tityus serrulatus (Ts) is the main scorpion species of medical importance in Brazil. Ts venom
is composed of several compounds such as mucus, inorganic salts, lipids, amines …
is composed of several compounds such as mucus, inorganic salts, lipids, amines …
TLR2, TLR4 and CD14 Recognize Venom-Associated Molecular Patterns from Tityus serrulatus to Induce Macrophage-Derived Inflammatory Mediators
Scorpion sting-induced human envenomation provokes an intense inflammatory reaction.
However, the mechanisms behind the recognition of scorpion venom and the induction of …
However, the mechanisms behind the recognition of scorpion venom and the induction of …
Microparticles prepared with 50–190 kDa chitosan as promising non-toxic carriers for pulmonary delivery of isoniazid
Chitosan biocompatibility and mucoadhesiveness make it an ideal polymer for
antituberculotic drugs microcapsulation for pulmonary delivery. Yet, previous study indicated …
antituberculotic drugs microcapsulation for pulmonary delivery. Yet, previous study indicated …
Biological effects of animal venoms on the human immune system
Z Avalo, MC Barrera, M Agudelo-Delgado, GJ Tobón… - Toxins, 2022 - mdpi.com
Venoms are products of specialized glands and serve many living organisms to immobilize
and kill prey, start digestive processes and act as a defense mechanism. Venoms affect …
and kill prey, start digestive processes and act as a defense mechanism. Venoms affect …
Immunological responses to envenomation
Venoms are complex mixtures of toxic compounds delivered by bite or sting. In humans, the
consequences of envenomation range from self-limiting to lethal. Critical host defence …
consequences of envenomation range from self-limiting to lethal. Critical host defence …
Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
MB Reis, FL Rodrigues, N Lautherbach… - Nature …, 2020 - nature.com
Scorpion envenomation is a leading cause of morbidity and mortality among accidents
caused by venomous animals. Major clinical manifestations that precede death after …
caused by venomous animals. Major clinical manifestations that precede death after …