DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …

Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …

Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via
cGAS-STING pathway activation and, when oxidized (Ox-mtDNA), it binds cytosolic NLRP3 …

Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

Neurodegenerative diseases are hereditary or sporadic conditions that result in the
progressive loss of the structure and function of neurons as well as neuronal death …

Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …

Endogenous and exogenous sources cause oxidatively induced DNA damage in living
organisms by a variety of mechanisms. The resulting DNA lesions are mutagenic and …

Despite the emergence of mitochondria as key regulators of innate immunity, the
mechanisms underlying the generation and release of immunostimulatory alarmins by …

Increasing evidence supports a role for oxidative DNA damage in aging and several
neurodegenerative diseases including Alzheimer's disease (AD). Attack of DNA by reactive …

Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …