Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
Phospholipase A2 structure/function, mechanism, and signaling1
JE Burke, EA Dennis - Journal of lipid research, 2009 - ASBMB
Tremendous advances in understanding the structure and function of the superfamily of
phospholipase A 2 (PLA 2) enzymes has occurred in the twenty-first century. The …
phospholipase A 2 (PLA 2) enzymes has occurred in the twenty-first century. The …
Recent progress in phospholipase A2 research: from cells to animals to humans
M Murakami, Y Taketomi, Y Miki, H Sato… - Progress in lipid …, 2011 - Elsevier
Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …
related enzymes, which are subdivided into several classes including low-molecular-weight …
The phospholipase A2 superfamily and its group numbering system
RH Schaloske, EA Dennis - … et Biophysica Acta (BBA)-Molecular and Cell …, 2006 - Elsevier
The superfamily of phospholipase A2 (PLA2) enzymes currently consists of 15 Groups and
many subgroups and includes five distinct types of enzymes, namely the secreted PLA2s …
many subgroups and includes five distinct types of enzymes, namely the secreted PLA2s …
The metabolic serine hydrolases and their functions in mammalian physiology and disease
JZ Long, BF Cravatt - Chemical reviews, 2011 - ACS Publications
Serine hydrolases (SHs) consist of> 200 enzymes in humans characterized by the presence
of an active site serine that is used for the hydrolysis of substrates. The membership of this …
of an active site serine that is used for the hydrolysis of substrates. The membership of this …
The combined human sperm proteome: cellular pathways and implications for basic and clinical science
BACKGROUND The human sperm cell is very well suited for proteomic studies, as it is
accessible, can be easily purified and is believed to be transcriptionally and translationally …
accessible, can be easily purified and is believed to be transcriptionally and translationally …
Calcium-independent phospholipases A2 and their roles in biological processes and diseases
Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …
Mitochondrial Dysfunction and β‐Cell Failure in Type 2 Diabetes Mellitus
ZA Ma, Z Zhao, J Turk - Journal of Diabetes Research, 2012 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is the most common human endocrine disease and is
characterized by peripheral insulin resistance and pancreatic islet β‐cell failure …
characterized by peripheral insulin resistance and pancreatic islet β‐cell failure …
Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
PC Kienesberger, M Oberer, A Lass, R Zechner - Journal of lipid research, 2009 - ASBMB
The human genome expresses nine patatin-like phospholipase domain containing proteins
(PNPLA1–9). Members of this family share a protein domain discovered initially in patatin …
(PNPLA1–9). Members of this family share a protein domain discovered initially in patatin …
Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases
Arachidonic acid (AA) and its oxygenated derivatives, collectively known as the eicosanoids,
are key mediators of a wide variety of physiological and pathophysiological states. AA …
are key mediators of a wide variety of physiological and pathophysiological states. AA …