Targeting amyloid aggregation: an overview of strategies and mechanisms

S Giorgetti, C Greco, P Tortora, FA Aprile - International journal of …, 2018 - mdpi.com
Amyloids result from the aggregation of a set of diverse proteins, due to either specific
mutations or promoting intra-or extra-cellular conditions. Structurally, they are rich in …

Curcumin in health and diseases: Alzheimer's disease and curcumin analogues, derivatives, and hybrids

E Chainoglou, D Hadjipavlou-Litina - International journal of molecular …, 2020 - mdpi.com
Worldwide, Alzheimer's disease (AD) is the most common neurodegenerative multifactorial
disease influencing the elderly population. Nowadays, several medications, among them …

Molecular hybridization as a tool in the design of multi-target directed drug candidates for neurodegenerative diseases

VS Gontijo, FPD Viegas, CJC Ortiz… - Current …, 2020 - ingentaconnect.com
Neurodegenerative Diseases (NDs) are progressive multifactorial neurological pathologies
related to neuronal impairment and functional loss from different brain regions. Currently, no …

Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands

L Blaikie, G Kay, PKT Lin - MedChemComm, 2019 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major
cause of death worldwide. The number of people suffering from this debilitating disorder is …

The potency of heterocyclic curcumin analogues: An evidence-based review

FC Rodrigues, NVA Kumar, G Thakur - Pharmacological Research, 2021 - Elsevier
Curcumin, a potent phytochemical, has been a significant lead compound and has been
extensively investigated for its multiple bioactivities. Owing to its natural origin, non-toxic …

A state of the art of antioxidant properties of curcuminoids in neurodegenerative diseases

S Silvestro, C Sindona, P Bramanti… - International Journal of …, 2021 - mdpi.com
Neurodegenerative diseases represent a set of pathologies characterized by an irreversible
and progressive, and a loss of neuronal cells in specific areas of the brain. Oxidative …

Interactions between curcumin derivatives and amyloid-β fibrils: insights from molecular dynamics simulations

JM Jakubowski, AA Orr, DA Le… - Journal of chemical …, 2019 - ACS Publications
The aggregation of amyloid-β (Aβ) peptides into senile plaques is a hallmark of Alzheimer's
disease (AD) and is hypothesized to be the primary cause of AD related neurodegeneration …

Evaluation of the status quo of polyphenols analysis: Part I—phytochemistry, bioactivity, interactions, and industrial uses

AS Silva, P Reboredo‐Rodríguez… - … Reviews in Food …, 2020 - Wiley Online Library
Phytochemicals, especially polyphenols, are gaining more attention from both the scientific
community and food, pharmaceutical, and cosmetics industries due to their implications in …

Nanoneuromedicine for management of neurodegenerative disorder

N Dwivedi, J Shah, V Mishra, M Tambuwala… - Journal of Drug Delivery …, 2019 - Elsevier
Conventional drug delivery systems are inadequate in providing essential cyto-architecture
restoration and connection patterns because of restrictions posed by the restrictive blood …

Curcumin as scaffold for drug discovery against neurodegenerative diseases

F Lo Cascio, P Marzullo, R Kayed… - Biomedicines, 2021 - mdpi.com
Neurodegenerative diseases (NDs) are one of major public health problems and their
impact is continuously growing. Curcumin has been proposed for the treatment of several of …