Epigenetic processes such as DNA methylation are considered key mechanisms at the
crossroads between genetics and environment in the etiology of mental disorders. The …

During the critical developmental periods of childhood when neural plasticity is high,
exposure to early life stress (ELS) or trauma may lead to enduring changes in physiological …

Alcohol-use-disorders are chronic relapsing illnesses, often co-morbid with anxiety. We
have previously shown using the “drinking-in-the-dark” model in mice that the stimulation of …

Monoamine oxidases, both MAO-A and MAO-B, have been implicated in personality traits
and complex behaviour, including drug use. Findings supporting the involvement of MAO-A …

A current survey and synthesis of the most important findings in our understanding of the
neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series …

The use of non-human primates (NHPs) in studies of volitional, oral self-administration of
alcohol can help address the complex interplay between stress and excessive alcohol …

Chronic alcohol abuse is frequently considered a habitual or inflexible behavior; however,
measures of pre-existing cognitive flexibility prior to initiation of alcohol use are usually not …

Cognitive impairments, uncontrolled drinking, and neuropathological cortical changes
characterize alcohol use disorder. Dysfunction of the orbitofrontal cortex (OFC), a critical …

Alterations in DNA methylation have been associated with alcohol exposure and proposed
to contribute to continued alcohol use; however, the molecular mechanisms involved remain …

Puerariae Flos, a representative homology plant of medicine and food for alcoholism, has a
long history of clinical experience and remarkable curative effect in the treatment of alcoholic …