Thiazole-containing compounds as therapeutic targets for cancer therapy
In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …
development, and several new anticancer agents of natural and synthetic origin have been …
Heterocyclic scaffolds: centrality in anticancer drug development
I Ali, M Nadeem Lone, Z A. Al-Othman… - Current drug …, 2015 - benthamdirect.com
Cancer has been cursed for human beings for long time. Millions people lost their lives due
to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; …
to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; …
Synthesis and characterization of novel thiazole derivatives as potential anticancer agents: Molecular docking and DFT studies
New thiazole derivatives (2a-l) were synthesized via the reaction of 2-(3-cyano-4-
isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid with substituted phenyl amines. The …
isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid with substituted phenyl amines. The …
Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update
K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …
A review on recent synthetic strategies and pharmacological importance of 1, 3-thiazole derivatives
S Nayak, SL Gaonkar - Mini reviews in medicinal chemistry, 2019 - ingentaconnect.com
Thiazole is the most common heterocyclic compound in heterocyclic chemistry and in drug
design. Presence of several reaction sites in the thiazole moiety extends their range of …
design. Presence of several reaction sites in the thiazole moiety extends their range of …
Design and synthesis of novel anti-urease imidazothiazole derivatives with promising antibacterial activity against Helicobacter pylori
Urease enzyme is a known therapeutic drug target for treatment of Helicobacter pylori
infection due to its role in settlement and growth in gastric mucosa. In this study, we …
infection due to its role in settlement and growth in gastric mucosa. In this study, we …
An overview on synthetic 2-aminothiazole-based compounds associated with four biological activities
M Farouk Elsadek, B Mohamed Ahmed… - Molecules, 2021 - mdpi.com
Amongst sulfur-and nitrogen-containing heterocyclic compounds, the 2-aminothiazole
scaffold is one of the characteristic structures in drug development as this essential …
scaffold is one of the characteristic structures in drug development as this essential …
Anticancer potential of thiazole derivatives: a retrospective review
S Jain, S Pattnaik, K Pathak, S Kumar… - Mini reviews in …, 2018 - ingentaconnect.com
This review brings forth the potential of thiazole derivatives for their anticancer activities. The
emphasis is placed on the structural diversity of thiazole derivatives, responsible for their …
emphasis is placed on the structural diversity of thiazole derivatives, responsible for their …
Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo [2, 1-b] thiazole derivatives bearing pyrazole moieties
Abstract A series of imidazo [2, 1-b] thiazoles bearing pyrazole moieties 4–6 (a–c) was
synthesized through the reaction of 6-hydrazinylimidazo [2, 1-b] thiazoles 3a–c with different …
synthesized through the reaction of 6-hydrazinylimidazo [2, 1-b] thiazoles 3a–c with different …
Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
ML Fascio, MI Errea, NB D'accorso - European journal of medicinal …, 2015 - Elsevier
Fused heterobicyclic systems have gained much importance in the field of medicinal
chemistry because of their broad spectrum of physiological activities. Among the …
chemistry because of their broad spectrum of physiological activities. Among the …