Thiazole-containing compounds as therapeutic targets for cancer therapy

PC Sharma, KK Bansal, A Sharma, D Sharma… - European journal of …, 2020 - Elsevier
In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …

Heterocyclic scaffolds: centrality in anticancer drug development

I Ali, M Nadeem Lone, Z A. Al-Othman… - Current drug …, 2015 - benthamdirect.com
Cancer has been cursed for human beings for long time. Millions people lost their lives due
to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; …

Synthesis and characterization of novel thiazole derivatives as potential anticancer agents: Molecular docking and DFT studies

R Raveesha, AM Anusuya, AV Raghu, KY Kumar… - Computational …, 2022 - Elsevier
New thiazole derivatives (2a-l) were synthesized via the reaction of 2-(3-cyano-4-
isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid with substituted phenyl amines. The …

Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …

A review on recent synthetic strategies and pharmacological importance of 1, 3-thiazole derivatives

S Nayak, SL Gaonkar - Mini reviews in medicinal chemistry, 2019 - ingentaconnect.com
Thiazole is the most common heterocyclic compound in heterocyclic chemistry and in drug
design. Presence of several reaction sites in the thiazole moiety extends their range of …

Design and synthesis of novel anti-urease imidazothiazole derivatives with promising antibacterial activity against Helicobacter pylori

AI Shahin, S Zaib, SO Zaraei, RA Kedia, HS Anbar… - PLoS …, 2023 - journals.plos.org
Urease enzyme is a known therapeutic drug target for treatment of Helicobacter pylori
infection due to its role in settlement and growth in gastric mucosa. In this study, we …

An overview on synthetic 2-aminothiazole-based compounds associated with four biological activities

M Farouk Elsadek, B Mohamed Ahmed… - Molecules, 2021 - mdpi.com
Amongst sulfur-and nitrogen-containing heterocyclic compounds, the 2-aminothiazole
scaffold is one of the characteristic structures in drug development as this essential …

Anticancer potential of thiazole derivatives: a retrospective review

S Jain, S Pattnaik, K Pathak, S Kumar… - Mini reviews in …, 2018 - ingentaconnect.com
This review brings forth the potential of thiazole derivatives for their anticancer activities. The
emphasis is placed on the structural diversity of thiazole derivatives, responsible for their …

Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo [2, 1-b] thiazole derivatives bearing pyrazole moieties

AR Ali, ER El-Bendary, MA Ghaly, IA Shehata - European journal of …, 2014 - Elsevier
Abstract A series of imidazo [2, 1-b] thiazoles bearing pyrazole moieties 4–6 (a–c) was
synthesized through the reaction of 6-hydrazinylimidazo [2, 1-b] thiazoles 3a–c with different …

Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties

ML Fascio, MI Errea, NB D'accorso - European journal of medicinal …, 2015 - Elsevier
Fused heterobicyclic systems have gained much importance in the field of medicinal
chemistry because of their broad spectrum of physiological activities. Among the …