Systemic and organ-specific anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors
Inflammation plays an essential role and is a common feature in the pathogenesis of many
chronic diseases. The exact mechanisms through which sodium-glucose cotransporter-2 …
chronic diseases. The exact mechanisms through which sodium-glucose cotransporter-2 …
Implication of M2 macrophage on NLRP3 inflammasome signaling in mediating the neuroprotective effect of Canagliflozin against methotrexate-induced cognitive …
LH Khedr, RM Rahmo, OM Eldemerdash… - International …, 2024 - Elsevier
Methotrexate (MTX), a chemotherapeutic antimetabolite, has been linked to cognitive
impairment in cancer patients. MTX-induced metabolic pathway disruption may result in …
impairment in cancer patients. MTX-induced metabolic pathway disruption may result in …
The alleviative effects of canagliflozin on imiquimod-induced mouse model of psoriasis-like inflammation
H Ridha-Salman, AA Al-Zubaidy, AH Abbas… - Naunyn-Schmiedeberg's …, 2024 - Springer
Psoriasis is a life-long immune-mediated dermatosis with thickened, reddish, and flaky skin
patches. Canagliflozin is a gliflozin antidiabetic with non-classical remarkable antioxidative …
patches. Canagliflozin is a gliflozin antidiabetic with non-classical remarkable antioxidative …
Hepatoprotective effects of the xanthine oxidase inhibitor Febuxostat against thioacetamide-induced liver injury in rats: The role of the Nrf2/HO-1 and TLR4/NF-κB …
RS Abdelrahman, ME Abdelmageed - Food and Chemical Toxicology, 2024 - Elsevier
Experimental models of liver injury have been established utilizing thioacetamide (TAA), a
classic liver toxic chemical that causes organ damage via oxidative stress and inflammatory …
classic liver toxic chemical that causes organ damage via oxidative stress and inflammatory …
[HTML][HTML] RAGE/DIAPH1 and atherosclerosis through an evolving lens: Viewing the cell from the “inside–Out”
R Ramasamy, A Shekhtman, AM Schmidt - Atherosclerosis, 2024 - Elsevier
Background and aims In hyperglycemia, inflammation, oxidative stress and aging, Damage
Associated Molecular Patterns (DAMPs) accumulate in conditions such as atherosclerosis …
Associated Molecular Patterns (DAMPs) accumulate in conditions such as atherosclerosis …
Targeting angiogenic and proliferative mediators by montelukast & trimetazidine Ameliorates thioacetamide-induced liver fibrosis in rats
RS Abdelrahman, AA Elnfarawy, AE Nashy… - Toxicology and Applied …, 2024 - Elsevier
Liver fibrosis is a significant health complication with the potential to result in serious
mortality and morbidity. However, there is no standard treatment due to its complex …
mortality and morbidity. However, there is no standard treatment due to its complex …
Berberine attenuates ECM accumulation and the progression of acute liver failure through inhibition of NLRP3 inflammasome signalling
SA Ali, AK Datusalia - Toxicology and Applied Pharmacology, 2024 - Elsevier
Acute liver failure (ALF) is a life-threatening disease, characterized by upregulated
extracellular matrix deposition and inflammatory signalling, with no effective treatment …
extracellular matrix deposition and inflammatory signalling, with no effective treatment …
Activation of AMPK/mTOR-Driven Autophagy and Suppression of the HMGB1/TLR4 Pathway with Pentoxifylline Attenuates Doxorubicin-Induced Hepatic Injury in Rats
HH Arab, AH Eid, SE Alsufyani, AM Ashour… - Pharmaceuticals, 2024 - mdpi.com
Despite being an effective chemotherapeutic agent, the clinical use of doxorubicin (DOX) is
limited by several organ toxicities including hepatic injury. Pentoxifylline (PTX) is a …
limited by several organ toxicities including hepatic injury. Pentoxifylline (PTX) is a …
Protective effects of insulin on dry eye syndrome via TLR4/NF-κB pathway: based on network pharmacology and in vitro experiments validation
X Yuan, Y Zhang, S Wang, Z Du - Frontiers in Pharmacology, 2024 - frontiersin.org
Dry eye syndrome (DES) is a multifactorial ocular surface disease and represents one of the
most prevalent ophthalmic disorders. Insulin is an important metabolism-regulating hormone …
most prevalent ophthalmic disorders. Insulin is an important metabolism-regulating hormone …
Gliflozins as remedies for correction of non-alcoholic fatty liver disease neurological complications. Part 2
VA Prikhodko, SV Okovityi - Therapy, 2024 - journals.eco-vector.com
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have a
number of common risk factors with central nervous system lesions, and are also an …
number of common risk factors with central nervous system lesions, and are also an …