Multi-target drugs active against leishmaniasis: A paradigm of drug repurposing

SS Braga - European Journal of Medicinal Chemistry, 2019 - Elsevier
This mini-review focuses on leishmanicidal drugs that were sourced from small molecules
previously approved for other diseases. The mechanisms of action of these molecules are …

Thermo-L-Asparaginases: From the role in the viability of thermophiles and hyperthermophiles at high temperatures to a molecular understanding of their …

M Dumina, A Zhgun - International Journal of Molecular Sciences, 2023 - mdpi.com
L-asparaginase (L-ASNase) is a vital enzyme with a broad range of applications in
medicine, food industry, and diagnostics. Among various organisms expressing L-ASNases …

Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response

EA Alpizar-Sosa, NRB Ithnin, W Wei… - PLoS Neglected …, 2022 - journals.plos.org
Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen
independent lines of Leishmania mexicana and one L. infantum line were selected for …

Design, synthesis, and biological evaluation of 3, 3′-diindolylmethane N-linked glycoconjugate as a leishmanial topoisomerase IB inhibitor with reduced cytotoxicity

P Kour, P Saha, S Bhattacharya, D Kumari… - RSC Medicinal …, 2023 - pubs.rsc.org
Leishmaniasis, one of the neglected diseases, ranks second to malaria in the cause of
parasitic mortality and morbidity. The present chemotherapeutic regimen faces the …

Drugs and nanoformulations for the management of Leishmania infection: a patent and literature review (2015-2022)

M Verdan, I Taveira, F Lima, F Abreu… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Leishmaniasis is an important disease caused by parasites of the Leishmania.
Due to the urgent need for financial incentives and research and development of new anti …

Slow pace of antileishmanial drug development

A Kumar, SC Pandey, M Samant - Parasitology Open, 2018 - cambridge.org
The protozoan parasite Leishmania is endemic in large parts of the world which causes
leishmaniasis. Its visceral form is fatal if not treated and is caused mostly by Leishmania …

Identification of trans-2-cis-8-Matricaria-ester from the Essential Oil of Erigeron multiradiatus and Evaluation of Its Antileishmanial Potential by in Vitro and in Silico …

S Chandra Pandey, DS Dhami, A Jha… - ACS …, 2019 - ACS Publications
The essential oil (EO) composition of the aerial parts of Erigeron multiradiatus (Lindl. ex DC.)
Benth growing wild in the central Himalayan region of Uttarakhand, India, was analyzed by …

Antimicrobial‐resistant Neisseria gonorrhoeae can be targeted using inhibitors against evolutionary conservedl‐asparaginase

S Vashishtha, J Singh, B Kundu - Journal of cellular …, 2022 - Wiley Online Library
The emergence of multiple drug‐resistant “super gonorrhoea” complicates the management
and treatment of Neisseria gonorrhoeae infections due to the progressive accumulation of …

Anhydroparthenin as a dual-target inhibitor against Sterol C-24 methyltransferase and Sterol 14-α demethylase of Leishmania donovani: A comprehensive in vitro and …

D Kumari, P Kour, CP Singh, R Choudhary… - International Journal of …, 2024 - Elsevier
Parthenium hysterophorus plant has a diverse chemical profile and immense bioactive
potential. It exhibits excellent pharmacological properties such as anti-cancer, anti …

Adjuvant effects of TLR agonist gardiquimod admixed with Leishmania vaccine in mice model of visceral leishmaniasis

DK Goyal, P Keshav, S Kaur - Infection, Genetics and Evolution, 2021 - Elsevier
Tropical and subtropical areas of the world are affected by leishmaniasis, which is caused
by Leishmania spp. It has been categorized as an NTD (neglected tropical disease) …