Drug-eluting implants are one of the leading implant technologies to facilitate the healing
capacity of bones by eliminating implant-associated infections. Treatment of the infections …

Non-oral long-acting drug delivery systems (LADDS) encompass a range of technologies for
precisely delivering drug molecules into target tissues either through the systemic circulation …

The rising significance of the field of biopolymers has driven the rapid progress of this
distinctive class of polymeric materials in the past decades. Biodegradable polymers have …

Ultra-long-acting integrase strand transfer inhibitors were created by screening a library of
monomeric and dimeric dolutegravir (DTG) prodrug nanoformulations. This led to an 18 …

Introduction Poor or inconsistent adherence to daily oral pre-exposure prophylaxis (PrEP)
has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting …

Abstract 3D Printing offers a considerable potential for personalized medicines. This is
especially true for customized biodegradable implants, matching the specific needs of each …

The excellent properties of polyesters combined with their ease of synthesis and
modification enabled their wide use in the pharmaceutical industry. This has been translated …

Different types of ibuprofen-loaded, poly (D, L lactic-co-glycolic acid)(PLGA)-based implants
were prepared by 3D printing (Droplet Deposition Modeling). The theoretical filling density of …

The aim of this study was to better understand the importance of the diameter of poly (lactic-
co-glycolic acid)(PLGA)-based implants on system performance, in particular the control of …

Lack of adherence is a key barrier to a successful human immunodeficiency virus (HIV)
treatment and prevention. We report on an ultra-long-acting (ULA) biodegradable polymeric …