Pericytes in the disease spotlight

H van Splunder, P Villacampa, A Martínez-Romero… - Trends in Cell …, 2023 - cell.com
Pericytes are known as the mural cells in small-caliber vessels that interact closely with the
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …

Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets

S Nian, ACY Lo, Y Mi, K Ren, D Yang - Eye and Vision, 2021 - Springer
Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading
cause of visual loss in working-age individuals in many industrialized countries. It has been …

Diabetic retinopathy: Involved cells, biomarkers, and treatments

J Ren, S Zhang, Y Pan, M Jin, J Li, Y Luo… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy (DR), a leading cause of vision loss and blindness worldwide, is
caused by retinal neurovascular unit dysfunction, and its cellular pathology involves at least …

Distinct signatures of calcium activity in brain mural cells

C Glück, KD Ferrari, N Binini, A Keller, AS Saab… - Elife, 2021 - elifesciences.org
Pericytes have been implicated in various neuropathologies, yet little is known about their
function and signaling pathways in health. Here, we characterized calcium dynamics of …

Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury

SF Abcouwer, S Shanmugam, A Muthusamy… - Journal of …, 2021 - Springer
Background Several retinal pathologies exhibit both inflammation and breakdown of the
inner blood-retinal barrier (iBRB) resulting in vascular permeability, suggesting that …

Pericyte mechanics and mechanobiology

CA Dessalles, A Babataheri… - Journal of Cell …, 2021 - journals.biologists.com
Pericytes are mural cells of the microvasculature, recognized by their thin processes and
protruding cell body. Pericytes wrap around endothelial cells and play a central role in …

Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy

RJ Phang, RH Ritchie, DJ Hausenloy… - Cardiovascular …, 2023 - academic.oup.com
Patients with Type 2 diabetes mellitus (T2DM) frequently exhibit a distinctive cardiac
phenotype known as diabetic cardiomyopathy. Cardiac complications associated with T2DM …

Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip

TL Maurissen, AJ Spielmann, G Schellenberg… - Nature …, 2024 - nature.com
Diabetic retinopathy (DR) is a microvascular disorder characterized by inner blood-retinal
barrier (iBRB) breakdown and irreversible vision loss. While the symptoms of DR are known …

[HTML][HTML] Emerging links between cerebral blood flow regulation and cognitive decline: A role for brain microvascular pericytes

TY You, Q Dong, M Cui - Aging and Disease, 2023 - ncbi.nlm.nih.gov
Cognitive impairment associated with vascular etiology has been of considerable interest in
the development of dementia. Recent studies have started to uncover cerebral blood flow …

Reaver: a program for improved analysis of high‐resolution vascular network images

BA Corliss, RW Doty, C Mathews, PA Yates… - …, 2020 - Wiley Online Library
Alterations in vascular networks, including angiogenesis and capillary regression, play key
roles in disease, wound healing, and development. The spatial structures of blood vessels …