Pericytes in the disease spotlight
H van Splunder, P Villacampa, A Martínez-Romero… - Trends in Cell …, 2023 - cell.com
Pericytes are known as the mural cells in small-caliber vessels that interact closely with the
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …
Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets
S Nian, ACY Lo, Y Mi, K Ren, D Yang - Eye and Vision, 2021 - Springer
Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading
cause of visual loss in working-age individuals in many industrialized countries. It has been …
cause of visual loss in working-age individuals in many industrialized countries. It has been …
Diabetic retinopathy: Involved cells, biomarkers, and treatments
J Ren, S Zhang, Y Pan, M Jin, J Li, Y Luo… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy (DR), a leading cause of vision loss and blindness worldwide, is
caused by retinal neurovascular unit dysfunction, and its cellular pathology involves at least …
caused by retinal neurovascular unit dysfunction, and its cellular pathology involves at least …
Distinct signatures of calcium activity in brain mural cells
Pericytes have been implicated in various neuropathologies, yet little is known about their
function and signaling pathways in health. Here, we characterized calcium dynamics of …
function and signaling pathways in health. Here, we characterized calcium dynamics of …
Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury
SF Abcouwer, S Shanmugam, A Muthusamy… - Journal of …, 2021 - Springer
Background Several retinal pathologies exhibit both inflammation and breakdown of the
inner blood-retinal barrier (iBRB) resulting in vascular permeability, suggesting that …
inner blood-retinal barrier (iBRB) resulting in vascular permeability, suggesting that …
Pericyte mechanics and mechanobiology
CA Dessalles, A Babataheri… - Journal of Cell …, 2021 - journals.biologists.com
Pericytes are mural cells of the microvasculature, recognized by their thin processes and
protruding cell body. Pericytes wrap around endothelial cells and play a central role in …
protruding cell body. Pericytes wrap around endothelial cells and play a central role in …
Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy
RJ Phang, RH Ritchie, DJ Hausenloy… - Cardiovascular …, 2023 - academic.oup.com
Patients with Type 2 diabetes mellitus (T2DM) frequently exhibit a distinctive cardiac
phenotype known as diabetic cardiomyopathy. Cardiac complications associated with T2DM …
phenotype known as diabetic cardiomyopathy. Cardiac complications associated with T2DM …
Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip
TL Maurissen, AJ Spielmann, G Schellenberg… - Nature …, 2024 - nature.com
Diabetic retinopathy (DR) is a microvascular disorder characterized by inner blood-retinal
barrier (iBRB) breakdown and irreversible vision loss. While the symptoms of DR are known …
barrier (iBRB) breakdown and irreversible vision loss. While the symptoms of DR are known …
[HTML][HTML] Emerging links between cerebral blood flow regulation and cognitive decline: A role for brain microvascular pericytes
TY You, Q Dong, M Cui - Aging and Disease, 2023 - ncbi.nlm.nih.gov
Cognitive impairment associated with vascular etiology has been of considerable interest in
the development of dementia. Recent studies have started to uncover cerebral blood flow …
the development of dementia. Recent studies have started to uncover cerebral blood flow …
Reaver: a program for improved analysis of high‐resolution vascular network images
BA Corliss, RW Doty, C Mathews, PA Yates… - …, 2020 - Wiley Online Library
Alterations in vascular networks, including angiogenesis and capillary regression, play key
roles in disease, wound healing, and development. The spatial structures of blood vessels …
roles in disease, wound healing, and development. The spatial structures of blood vessels …