The study of genes mutated in human disease often leads to new insights into biology as
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …

There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …

Cellular interactions among nephron, interstitial, and collecting duct progenitors drive
mammalian kidney development. In mice, Six2+ nephron progenitor cells (NPCs) and …

Summary FGF, BMP, and WNT balance embryonic nephron progenitor cell (NPC) renewal
and differentiation. By modulating these pathways, we have created an in vitro niche in …

Fibroblast growth factors (FGFs) are a large family of secretory molecules that act through
tyrosine kinase receptors known as FGF receptors. They play crucial roles in a wide variety …

Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects
derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the …

Adrenal glands are zonated endocrine organs that are essential in controlling body
homeostasis. How zonation is induced and maintained and how renewal of the adrenal …

The transcription factor Wilms' tumor suppressor 1 (WT1) is key to podocyte development
and viability; however, WT1 transcriptional networks in podocytes remain elusive. We …

Nephron progenitors in the embryonic kidney propagate while generating differentiated
nephrons. However, in mice, the progenitors terminally differentiate shortly after birth. Here …

Development of the metanephric kidney is strongly dependent on complex signaling
pathways and cell–cell communication between at least four major progenitor cell …