Leprosy in the 21st century

C White, C Franco-Paredes - Clinical microbiology reviews, 2015 - Am Soc Microbiol
Despite significant improvements in leprosy (Hansen's disease) treatment and outlook for
patients since the introduction of multidrug therapy (MDT) 3 decades ago, the global …

Mycobacterium leprae: Pathogenesis, diagnosis, and treatment options

MR Mungroo, NA Khan, R Siddiqui - Microbial Pathogenesis, 2020 - Elsevier
Mycobacterium leprae is known to cause leprosy, a neurological and dermatological
disease. In the past 20 years, 16 million leprosy cases have been recorded and more than …

Use of protein antigens for early serological diagnosis of leprosy

MS Duthie, W Goto, GC Ireton, ST Reece… - Clinical and Vaccine …, 2007 - Am Soc Microbiol
Leprosy is a chronic and debilitating human disease caused by infection with the
Mycobacterium leprae bacillus. Despite the marked reduction in the number of registered …

Risk and protective factors for leprosy development determined by epidemiological surveillance of household contacts

IMB Goulart, DO Bernardes Souza… - Clinical and vaccine …, 2008 - Am Soc Microbiol
Household contacts of leprosy patients are the group with the highest risk of developing the
disease, and although many risk or prevention factors have been identified, they have not …

Leprosy: diagnostic and control challenges for a worldwide disease

IMB Goulart, LR Goulart - Archives of dermatological research, 2008 - Springer
Leprosy is a curable disease with well-defined etiology, but lacks better diagnostic tools,
preventive and therapeutic strategies. The continued application of the Ridley–Jopling …

Analysis of Antibody Responses to Mycobacterium leprae Phenolic Glycolipid I, Lipoarabinomannan, and Recombinant Proteins To Define Disease Subtype-Specific …

JS Spencer, HJ Kim, WH Wheat… - Clinical and Vaccine …, 2011 - Am Soc Microbiol
ABSTRACT A simple serodiagnostic test based on the Mycobacterium leprae-specific
phenolic glycolipid I (PGL-I), for individuals with leprosy is nearly universally positive in …

[HTML][HTML] Leprosy: a review of laboratory and therapeutic aspects-Part 2

JC Lastória, MAMM Abreu - Anais brasileiros de dermatologia, 2014 - SciELO Brasil
Leprosy is a chronic infectious condition caused by Mycobacterium leprae (M. leprae). It is
endemic in many regions of the world and a public health problem in Brazil. Additionally, it …

Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy

JS Spencer, MS Duthie, A Geluk… - Memórias do Instituto …, 2012 - SciELO Brasil
Although leprosy is curable with drug treatment, the identification of biomarkers of infection,
disease progression and treatment efficacy would greatly help to reduce the overall …

Immunologically reactive M. leprae antigens with relevance to diagnosis and vaccine development

LH Sampaio, MMA Stefani, RM Oliveira… - BMC infectious …, 2011 - Springer
Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae that
can manifest a wide variety of immunological and clinical outcomes ranging from potent …

Development of a quantitative rapid diagnostic test for multibacillary leprosy using smart phone technology

L Paula Vaz Cardoso, RF Dias, AA Freitas… - BMC infectious …, 2013 - Springer
Background Despite efforts to eliminate leprosy as public health problem, delayed diagnosis
and disabilities still occur in many countries. Leprosy diagnosis remains based on clinical …