J. Neurochem.(2012) 121, 4–27. Abstract Neuroglial cells define brain homeostasis and
mount defense against pathological insults. Astroglia regulate neurogenesis and …

Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to
active signaling and information processing in the brain. Contrary to this classical view, it is …

Neuronal activity is a high‐energy demanding process recruiting all neural cells that adapt
their metabolism to sustain the energy and redox balance of neurons. During …

Recent research has changed the perception of glia from being no more than silent
supportive cells of neurons to being dynamic partners participating in brain metabolism and …

Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …

Glutamine synthetase (GS) in brain is located mainly in astrocytes. One of the primary roles
of astrocytes is to protect neurons against excitotoxicity by taking up excess ammonia and …

Chemical transmission between neurons and glial cells is an important element of
integration in the CNS. Here, we describe currents activated by NMDA in cortical astrocytes …

Astrocytes regulate synaptic transmission and play a role in the formation of new memories,
long‐term potentiation (LTP), and functional synaptic plasticity. Specifically, astroglial …

Research on glutamatergic neurotransmission has focused mainly on the function of
presynaptic and postsynaptic neurons, leaving astrocytes with a secondary role only to …

Recent breakthroughs in neuroscience have led to the awareness that we should revise our
traditional mode of thinking and studying the CNS, ie by isolating the privileged network of …