Antiphospholipid syndrome

K Schreiber, S Sciascia, PG De Groot… - Nature reviews Disease …, 2018 - nature.com
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence
of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and …

The pathogenesis of the antiphospholipid syndrome

B Giannakopoulos, SA Krilis - New England Journal of Medicine, 2013 - Mass Medical Soc
The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies.
It is associated with obstetrical complications (mainly spontaneous abortion) as well as …

Pathogenesis of antiphospholipid syndrome: understanding the antibodies

PL Meroni, MO Borghi, E Raschi… - Nature Reviews …, 2011 - nature.com
Antiphospholipid antibodies (aPL) are both diagnostic markers for, and pathogenic drivers
of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre …

Diagnosing antiphospholipid syndrome:'extra-criteria'manifestations and technical advances

S Sciascia, MC Amigo, D Roccatello… - Nature Reviews …, 2017 - nature.com
First described in the early 1980s, antiphospholipid syndrome (APS) is a unique form of
acquired autoimmune thrombophilia in which patients present with clinical features of …

16th international congress on antiphospholipid antibodies task force report on antiphospholipid syndrome treatment trends

H Cohen, MJ Cuadrado, D Erkan, A Duarte-Garcia… - Lupus, 2020 - journals.sagepub.com
Antiphospholipid syndrome (APS), an acquired autoimmune thrombophilia, is characterised
by thrombosis and/or pregnancy morbidity in association with persistent antiphospholipid …

[HTML][HTML] The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS

T McDonnell, C Wincup, I Buchholz, C Pericleous… - Blood reviews, 2020 - Elsevier
Abstract Beta-2-Glycoprotein I (β2GPI) plays a number of essential roles throughout the
body. β2GPI, C-reactive protein and thrombomodulin are the only three proteins that …

14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends

ML Bertolaccini, O Amengual, L Andreoli, T Atsumi… - Autoimmunity …, 2014 - Elsevier
Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use
of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in …

14th international congress on antiphospholipid antibodies task force report on antiphospholipid syndrome treatment trends

D Erkan, CL Aguiar, D Andrade, H Cohen… - Autoimmunity …, 2014 - Elsevier
Antiphospholipid Syndrome (APS) is characterized by vascular thrombosis and/or
pregnancy morbidity occurring in patients with persistent antiphospholipid antibodies (aPL) …

β2-Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome

Ç Ağar, GMA van Os, M Mörgelin… - Blood, The Journal …, 2010 - ashpublications.org
The antiphospholipid syndrome is defined by the presence of antiphospholipid antibodies in
blood of patients with thrombosis or fetal loss. There is ample evidence that β2-glycoprotein I …

Guidelines for biomarkers in autoimmune rheumatic diseases-evidence based analysis

R Giacomelli, A Afeltra, A Alunno, E Bartoloni-Bocci… - Autoimmunity …, 2019 - Elsevier
Autoimmune rheumatic diseases are characterised by an abnormal immune system
response, complement activation, cytokines dysregulation and inflammation. In last years …