Therapeutic approaches employing RNA as a tool or as a drug target have recently
emerged and have been employed for various applications—ranging from cancer treatment …

Background RNA trans-splicing joins exons from different pre-mRNA transcripts to generate
a chimeric product. Trans-splicing can also occur at the protein level, with split inteins …

Hepatocellular carcinoma (HCC) has high fatality rate and limited therapeutic options. Here,
we propose a new anti-HCC approach with high cancer-selectivity and efficient anticancer …

Trans-splicing ribozyme enables to sense and reprogram target RNA into therapeutic
transgene and thereby becomes a good sensing device for detection of cancer cells, judging …

Aptamers bind to their targets with high affinity and specificity through structure-based
complementarity, instead of sequence complementarity that is used by most of the …

Hepatocellular carcinoma (HCC) has a high fatality rate and limited therapeutic options with
side effects and low efficacy. Here, we proposed a new anti-HCC approach based on cancer …

While many traditional gene therapy strategies attempt to deliver new copies of wild-type
genes back to cells harboring the defective genes, RNA-directed strategies offer a range of …

The advance of experimental and computational techniques has allowed us to highlight the
existence of numerous different mechanisms of RNA maturation, which have been so far …

Since the breakthrough discovery of catalytic RNAs (ribozymes) in the early 1980s, valuable
ribozyme‐based gene therapies have been developed for incurable diseases ranging from …

Despite the early promise of RNA therapeutics as a magic bullet to modulate aberrant
signaling in cancer, this field remains a work-in-progress. Nevertheless, RNA therapeutics is …