Molecular engineering of antimicrobial peptides: Microbial targets, peptide motifs and translation opportunities

P Cardoso, H Glossop, TG Meikle, A Aburto-Medina… - Biophysical …, 2021 - Springer
The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …

Activity and mechanism of action of antifungal peptides from microorganisms: a review

T Li, L Li, F Du, L Sun, J Shi, M Long, Z Chen - Molecules, 2021 - mdpi.com
Harmful fungi in nature not only cause diseases in plants, but also fungal infection and
poisoning when people and animals eat food derived from crops contaminated with them …

Food applications of liposome-encapsulated antimicrobial peptides

P da Silva Malheiros, DJ Daroit, A Brandelli - Trends in Food Science & …, 2010 - Elsevier
Antimicrobial peptides have been extensively examined as potential biopreservatives in
hurdle technology. However, stability issues like proteolytic degradation and the potential …

Antimicrobial peptides and induced membrane curvature: Geometry, coordination chemistry, and molecular engineering

NW Schmidt, GCL Wong - Current Opinion in Solid State and Materials …, 2013 - Elsevier
Short cationic, amphipathic antimicrobial peptides are multi-functional molecules that have
roles in host defense as direct microbicides and modulators of the immune response. While …

Toxicity of bovicin HC5 against mammalian cell lines and the role of cholesterol in bacteriocin activity

AD Paiva, MD de Oliveira, SO de Paula… - …, 2012 - microbiologyresearch.org
Bacteriocins are ribosomally synthesized antimicrobial peptides produced by Bacteria and
some Archaea. The assessment of the toxic potential of antimicrobial peptides is important in …

Rational design of stapled antimicrobial peptides

YH You, HY Liu, YZ Zhu, H Zheng - Amino Acids, 2023 - Springer
The global increase in antimicrobial drug resistance has dramatically reduced the
effectiveness of traditional antibiotics. Structurally diverse antibiotics are urgently needed to …

Nanostructures as promising tools for delivery of antimicrobial peptides

A Brandelli - Mini reviews in medicinal chemistry, 2012 - ingentaconnect.com
Antimicrobial peptides have been extensively investigated for their potential applications as
therapeutics and food biopreservatives. The antimicrobial activity may be impaired by the …

Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides?

JR Brender, AJ McHenry, A Ramamoorthy - Frontiers in immunology, 2012 - frontiersin.org
(Figure 1A). Cholesterol has been shown to protect human erythrocytes from attack by
magainin 2 (Matsuzaki et al., 1995b). Similar studies on model membranes have …

Selectivity of antimicrobial peptides: a complex interplay of multiple equilibria

S Bobone, L Stella - Antimicrobial Peptides: Basics for Clinical Application, 2019 - Springer
Antimicrobial peptides (AMPs) attack bacterial membranes selectively, killing microbes at
concentrations that cause no toxicity to the host cells. This selectivity is not due to interaction …

The structural and topological analysis of membrane-associated polypeptides by oriented solid-state NMR spectroscopy: established concepts and novel …

B Bechinger, JM Resende, C Aisenbrey - Biophysical chemistry, 2011 - Elsevier
Solid-state NMR spectroscopy is a powerful technique for the investigation of membrane-
associated peptides and proteins as well as their interactions with lipids, and a variety of …