Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …

Fibrillar protein aggregates are the pathological hallmark of a group of age‐dependent
neurodegenerative conditions, including Alzheimer's and Parkinson's disease. Aggregates …

Clusterin (CLU) is a highly evolutionary conserved glycoprotein with multiple isoform-
specific functions and is widely distributed in different species. Accumulated evidence has …

Background Cholangiocarcinoma (CCA) is a highly aggressive malignant tumor, and its
diagnosis is still a challenge. This study aimed to identify a novel bile marker for CCA …

In the oncological area, pancreatic cancer is one of the most lethal diseases, with 5-year
survival rising just 10% in high-development countries. This disease is genetically …

Mitophagy regulates cancer stem cell (CSC) populations affecting tumorigenicity and
malignancy in various cancer types. Here, we report that cisplatin treatment led to the …

Intra-tumoural heterogeneity and cancer cell plasticity in colorectal cancer (CRC) have been
key challenges to effective treatment for patients. It has been suggested that a subpopulation …

Colorectal cancer is the third most diagnosed cancer, behind only breast and lung cancer. In
terms of overall mortality, it ranks second due to, among other factors, problems with …

Background Colorectal cancer (CRC) is one of the most prevalent types of malignant
tumours. Metastasis is the leading cause of cancer-related mortality, with lung metastases …

Background It has been established that clusterin is involved in the invasion of immune cells
in the tumor microenvironment, but it remains unknown how it promotes immune invasion in …