The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

For decades, insight into fundamental principles of human biology and disease has been
obtained primarily by experiments in animal models. While this has allowed researchers to …

As new pathogens emerge, new challenges must be faced. This is no different in infectious
disease research, where identifying the best tools available in laboratories to conduct an …

Medicine today faces the combined challenge of an increasing number of untreatable
diseases and fewer drugs reaching the clinic. While pharmaceutical companies have …

It has recently been shown that an early SARS-CoV-2 isolate (NL-02-2020) hijacks
interferon-induced transmembrane proteins (IFITMs) for efficient replication in human lung …

The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of
unprecedented research efforts to understand the pathogenesis mediated by Severe Acute …

Background New COVID-19 treatments are desperately needed as case numbers continue
to rise and emergent strains threaten vaccine efficacy. Cell therapy has revolutionized …

Organoids are novel in vitro cell culture models that enable stem cells (including pluripotent
stem cells and adult stem cells) to grow and undergo self-organization within a three …

The COVID-19 pandemic has driven the scientific community to adopt an efficient and
reliable model that could keep up with the infectious disease arms race. Coinciding with the …

Respiratory tract infections (RTI) are a major cause of morbidity and mortality in humans. A
large number of RTIs is caused by viruses, often resulting in more severe disease in infants …