The pathophysiology of sepsis and septic shock involves complex cytokine and
inflammatory mediator networks. NF-κB activation is a central event leading to the activation …

Almost exactly twenty years after the discovery of Epstein-Barr virus (EBV), the latent
membrane protein 1 (LMP1) entered the EBV stage, and soon thereafter, it was recognized …

Epigenetic events that are essential drivers of lymphocyte transformation remain
incompletely characterized. We used models of Epstein-Barr virus (EBV)–induced B-cell …

To identify the molecular mechanisms by which EBV-associated epithelial cancers are
maintained, we measured the expression of essentially all human genes and all latent EBV …

Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that establishes a life-long
asymptomatic infection in immunocompetent hosts. It is also found to be frequently …

Epstein–Barr virus (EBV) was first discovered in cells from a patient with Burkitt lymphoma
(BL), and is now known to be a contributory factor in 1–2% of all cancers, for which there are …

A defining characteristic of the aggressive B cell tumour Burkitt's lymphoma (BL) is a
reciprocal chromosomal translocation that activates the Myc oncogene by juxtaposing it to …

Viral oncogenes are responsible for oncogenesis resulting from persistent virus infection.
Although different human tumor viruses express different viral oncogenes and induce …

Latent Epstein-Barr virus (EBV) infection is causally linked to several human cancers. EBV
expresses viral oncogenes that promote cell growth and inhibit the apoptotic response to …

Neutrophils have a very short half-life in the circulation, undergoing rapid death by
apoptosis, but a number of agents can either delay or accelerate the rate at which these …