Astrocyte dysfunction has previously been linked to multiple neurodegenerative disorders
including Parkinson's disease (PD). Among their many roles, astrocytes are mediators of the …

The molecular mechanisms of angiogenesis have been intensely studied, but many genes
that control endothelial behavior and fate still need to be described. Here, we characterize …

The pH value within the wound microenvironment influences indirectly and directly all
biochemical reactions taking place in the process of skin wound healing. Currently, it is …

Peripheral inflammation has been linked to various neurodegenerative disorders, including
Alzheimer's disease (AD). Here we perform bulk, single-cell, and spatial transcriptomics in …

Background Risk stratification and personalized care are crucial in managing osteosarcoma
due to its complexity and heterogeneity. However, current prognostic prediction using …

An in-depth literature review of up to 2023 reveals 330 risk loci found by genetic association
at p≤ 5× 10− 8, with systemic lupus erythematosus (SLE) in at least one study of 160 …

Transforming growth factor (TGF)-β signaling is a well-established pathogenic mediator of
diabetic kidney disease (DKD). However, owing to its pleiotropic actions, its systemic …

Background Bleeding disorder of unknown cause (BDUC) is characterised by a bleeding
phenotype in the setting of normal haemostatic testing. No standardised diagnostic criteria …

Introduction Investigation of the molecular basis of inherited bleeding disorders (IBD) is
mostly performed with gene panel sequencing. However, the continuous discovery of new …

Increased left ventricular mass has been associated with adverse cardiovascular outcomes
including incident cardiomyopathy and atrial fibrillation. Such associations have been …