Strain-level bacterial typing directly from patient samples using optical DNA mapping
M Nyblom, A Johnning, K Frykholm, M Wrande… - Communications …, 2023 - nature.com
Background Identification of pathogens is crucial to efficiently treat and prevent bacterial
infections. However, existing diagnostic techniques are slow or have a too low resolution for …
infections. However, existing diagnostic techniques are slow or have a too low resolution for …
Optical DNA mapping combined with Cas9-targeted resistance gene identification for rapid tracking of resistance plasmids in a neonatal intensive care unit outbreak
The global spread of antibiotic resistance among Enterobacteriaceae is largely due to
multidrug resistance plasmids that can transfer between different bacterial strains and …
multidrug resistance plasmids that can transfer between different bacterial strains and …
The resistomes of six carbapenem-resistant pathogens–a critical genotype–phenotype analysis
A Johnning, N Karami, E Tång Hallbäck… - Microbial …, 2018 - microbiologyresearch.org
Carbapenem resistance is a rapidly growing threat to our ability to treat refractory bacterial
infections. To understand how carbapenem resistance is mobilized and spread between …
infections. To understand how carbapenem resistance is mobilized and spread between …
Cultivation-free typing of bacteria using optical DNA mapping
A variety of pathogenic bacteria can infect humans, and rapid species identification is crucial
for the correct treatment. However, the identification process can often be time-consuming …
for the correct treatment. However, the identification process can often be time-consuming …
Enzyme-free optical DNA mapping of the human genome using competitive binding
Optical DNA mapping (ODM) allows visualization of long-range sequence information along
single DNA molecules. The data can for example be used for detecting long range structural …
single DNA molecules. The data can for example be used for detecting long range structural …
[HTML][HTML] High diversity of blaNDM-1-encoding plasmids in Klebsiella pneumoniae isolated from neonates in a Vietnamese hospital
Objectives The carbapenemase-encoding gene bla NDM-1 has been reported in Vietnam
during the last 10 years, and bla NDM-producing Enterobacteriaceae are now silently and …
during the last 10 years, and bla NDM-producing Enterobacteriaceae are now silently and …
Combining dense and sparse labeling in optical DNA mapping
Optical DNA mapping (ODM) is based on fluorescent labeling, stretching and imaging of
single DNA molecules to obtain sequence-specific fluorescence profiles, DNA barcodes …
single DNA molecules to obtain sequence-specific fluorescence profiles, DNA barcodes …
Identity of blaCTX-M Carrying Plasmids in Sequential ESBL-E. coli Isolates from Patients with Recurrent Urinary Tract Infections
Plasmid-mediated multidrug resistance in E. coli is becoming increasingly prevalent.
Considering this global threat to human health, it is important to understand how plasmid …
Considering this global threat to human health, it is important to understand how plasmid …
Genetic variation in the conjugative plasmidome of a hospital effluent multidrug resistant Escherichia coli strain
C Ferreira, D Bogas, SK Bikarolla, AR Varela… - Chemosphere, 2019 - Elsevier
Bacteria harboring conjugative plasmids have the potential for spreading antibiotic
resistance through horizontal gene transfer. It is described that the selection and …
resistance through horizontal gene transfer. It is described that the selection and …
Fluorescence Microscopy of Nanochannel-Confined DNA
S Kk, F Persson, J Fritzsche, JP Beech… - … Analysis: Methods and …, 2023 - Springer
Stretching of DNA in nanoscale confinement allows for several important studies. The
genetic contents of the DNA can be visualized on the single DNA molecule level, and the …
genetic contents of the DNA can be visualized on the single DNA molecule level, and the …