In drug development, a major reason for attrition is the lack of understanding of cellular
mechanisms governing drug toxicity. The black-box nature of conventional classification …

Thousands of epigenomic data sets have been generated in the past decade, but it is
difficult for researchers to effectively use all the data relevant to their projects. Systematic …

Yun Hao Li Shen Jason H. Moore In drug development, a major reason for attrition is the
lack of understanding of cellular mechanisms governing drug toxicity. Conventional models …

Chronic inflammatory diseases of the cardiovascular system, brain, gut, joints, skin and lung
are characterized by complex interactions between genetic predisposition and tissuespecific …

One essential goal in functional genomics is to understand the functions and functional
interactions of genes. The functional interaction between genes can happen in many ways …

Epigenetic modifications are intimately associated with many aspects of transcriptional
regulation, and thus, many epigenetic data sets have been generated under diverse …

“My goal is to solve biological problems,” says Olga Troyanskaya, who is on the Princeton
University faculty in computer science and at the Lewis-Sigler Institute for Integrative …