The international society of RNA nanotechnology and nanomedicine (ISRNN): the present and future of the burgeoning field

M Chandler, B Johnson, E Khisamutdinov… - ACS …, 2021 - ACS Publications
The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) hosts an
annual meeting series focused on presenting the latest research achievements involving …

Microfluidics facilitating the use of small extracellular vesicles in innovative approaches to male infertility

DM Goss, SA Vasilescu, G Sacks, DK Gardner… - Nature Reviews …, 2023 - nature.com
Sperm are transcriptionally and translationally quiescent and, therefore, rely on the seminal
plasma microenvironment for function, survival and fertilization of the oocyte in the oviduct …

[HTML][HTML] Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo

D Rufino-Ramos, S Lule, S Mahjoum, S Ughetto… - Biomaterials, 2022 - Elsevier
The lack of techniques to trace brain cell behavior in vivo hampers the ability to monitor
status of cells in a living brain. Extracellular vesicles (EVs), nanosized membrane …

Deletion of taf1 and taf5 in zebrafish capitulate cardiac and craniofacial abnormalities associated with TAFopathies through perturbations in metabolism

J Leid, R Gray, P Rakita, AL Koenig, R Tripathy… - Biology …, 2023 - journals.biologists.com
Intellectual disability is a neurodevelopmental disorder that affects 2-3% of the general
population. Syndromic forms of intellectual disability frequently have a genetic basis and are …

[HTML][HTML] Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing

KT Tshilenge, J Bons, CG Aguirre… - Neurobiology of …, 2024 - Elsevier
X-linked dystonia-parkinsonism (XDP) is a rare neurodegenerative disease endemic to the
Philippines. The genetic cause for XDP is an insertion of a SINE-VNTR-Alu (SVA)-type …

X-linked dystonia parkinsonism: epidemiology, genetics, clinical features, diagnosis, and treatment

HL Chin, CY Lin, OHI Chou - Acta Neurologica Belgica, 2023 - Springer
X-linked dystonia parkinsonism (XDP) is a rare X-linked recessive degenerative movement
disorder that only affects Filipino descent, predominantly males. Its underlying cause is …

G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism

G Nicoletto, M Terreri, I Maurizio… - Nucleic Acids …, 2024 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-canonical nucleic acid structures that form in
guanine (G)-rich genomic regions. X-linked dystonia parkinsonism (XDP) is an inherited …

[HTML][HTML] Extracellular communication between brain cells through functional transfer of Cre mRNA mediated by extracellular vesicles

D Rufino-Ramos, K Leandro, PRL Perdigão, K O'Brien… - Molecular Therapy, 2023 - cell.com
In the central nervous system (CNS), the crosstalk between neural cells is mediated by
extracellular mechanisms, including brain-derived extracellular vesicles (bdEVs). To study …

Tissue-specific and repeat length-dependent somatic instability of the X-linked dystonia parkinsonism-associated CCCTCT repeat

LN Campion, A Mejia Maza, R Yadav… - Acta neuropathologica …, 2022 - Springer
X-linked dystonia-parkinsonism (XDP) is a progressive adult-onset neurodegenerative
disorder caused by insertion of a SINE-VNTR-Alu (SVA) retrotransposon in the TAF1 gene …

Transcriptional Alterations in X-Linked Dystonia–Parkinsonism Caused by the SVA Retrotransposon

J Pozojevic, SM Algodon, JN Cruz, J Trinh… - International Journal of …, 2022 - mdpi.com
X-linked dystonia–parkinsonism (XDP) is a severe neurodegenerative disorder that
manifests as adult-onset dystonia combined with parkinsonism. A SINE-VNTR-Alu (SVA) …