The hippocampus is critical for learning and memory, relying in part on pattern separation
processes supported by the dentate gyrus (DG) to prevent interference from overlapping …

Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …

Higher order speeded cognitive abilities depend on efficient coordination of activity across
the brain, rendering them vulnerable to age reductions in structural and functional brain …

Pattern separation, or the process by which highly similar stimuli or experiences in memory
are represented by non-overlapping neural ensembles, has typically been ascribed to …

Normal aging is associated with a decline in episodic memory and also with aggregation of
the β-amyloid (Aβ) and tau proteins and atrophy of medial temporal lobe (MTL) structures …

Episodic memory relies on memory for the relations among multiple elements of an event
and the ability to discriminate among similar elements of episodes. The latter phenomenon …

Background: The fornix is the primary axonal tract of the hippocampus, connecting it to
modulatory subcortical structures. This review reveals that fornix damage causes cognitive …

Despite interindividual differences in cortical structure, cross‐sectional and longitudinal
studies have demonstrated a large degree of population‐level consistency in age‐related …

Structures of the medial temporal lobe (MTL) are known to be involved in declarative
memory processes. However, little is known about how age‐related changes in MTL …

Newer approaches to characterizing hippocampal morphology can provide novel insights
regarding cognitive function across the lifespan. We comprehensively assessed the …