Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …

Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-
associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl …

Stimulator of interferon genes (STING) orchestrates the production of proinflammatory
cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological …

Many cytosolic proteins lacking a signal peptide, called leaderless cargoes, are secreted
through unconventional secretion. Vesicle trafficking is a major pathway involved. It is …

Previous studies have demonstrated that cardiomyocyte apoptosis, ferroptosis, and
inflammation participate in the progress of sepsis-induced cardiomyopathy (SIC). Although …

Gasdermin D (GSDMD) participates in the activation of inflammasomes and pyroptosis.
Meanwhile, ubiquitination strictly regulates inflammatory responses. However, how …

Abstract The NLRP3 (NOD−, LRR− and pyrin domain-containing protein 3) inflammasome
plays a pivotal role in defending the host against infection as well as sterile inflammation …

The exact pathogenesis of inflammatory bowel disease (IBD), a chronic gastrointestinal
inflammatory disease comprising Crohn's disease and ulcerative colitis, remains unclear …

The cross presentation of exogenous antigen (Ag) by dendritic cells (DCs) facilitates a
diversified mode of T-cell activation, orchestrates specific humoral and cellular immunity …

The process of protein ubiquitination and deubiquitination plays an important role in
maintaining protein stability and regulating signal pathways, and protein homeostasis …