Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …

Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of
lethal signal transduction pathways converge on mitochondria to cause the permeabilization …

Background Pyroptosis is a lytic cell death form executed by gasdermins family proteins.
Induction of tumor pyroptosis promotes anti-tumor immunity and is a potential cancer …

Cancer cells have a very different metabolism from that of normal cells from which they are
derived. Their metabolism is elevated, which allows them to sustain higher proliferative rate …

The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic
metabolism, either as a consequence or as a cause. As an example, the resistance of …

It has been known for many years that cellular metabolism within the solid tumour is
markedly different from that of the corresponding normal tissue. The transcription factor …

Introduction• Intracellular pH regulation controls energy balance and cell proliferation:
chemical and biological proof of principle‐Chemical proof of principle‐Biological proof of …

Tumor formation and growth depend on various biological metabolism processes that are
distinctly different with normal tissues. Abnormal energy metabolism is one of the typical …

Cancer cells preferentially metabolize glucose through aerobic glycolysis. This
phenomenon, known as the Warburg effect, is an anomalous characteristic of glucose …

Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular
metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low …