Numerous surgical procedures are daily performed worldwide to replace and repair
damaged tissue. Tissue engineering is the field devoted to the regeneration of damaged …

Tissue engineering is considered one of the most important therapeutic strategies of
regenerative medicine. The main objective of these new technologies is the development of …

Blood–brain barrier (BBB) dysfunction, characterized by degradation of BBB junctional
proteins and increased permeability, is a crucial pathophysiological feature of acute …

Gelatin has various attractive features as biomedical materials, for instance, biocompatibility,
low immunogenicity, biodegradability, and ease of manipulation. In recent years, various …

Ischemic stroke is still a serious threat to human life and health, but there are few therapeutic
options available to treat stroke because of limited blood-brain penetration. The …

Dysregulation of brain iron levels causes functional disturbances and damages neurons.
Hepcidin (a peptide hormone) plays a principal role in regulating intracellular iron levels by …

Highlights•Stroke is the leading cause of adult disability.•In situ forming hydrogels can be
injected directly into the stroke cavity.•In situ forming hydrogels can be used to construct pro …

There is a broad range of biological, chemical and physical hurdles for drugs to reach the
brain. Nanoparticulate drug delivery systems hold tremendous potential for diagnosis and …

Ischemic stroke represents one of the most prevalent pathologies in humans and is a
leading cause of death and disability. Anti-thrombolytic therapy with tissue plasminogen …

The gelatin microsphere (GM) provides an attractive option for tissue engineering due to its
versatility, as reported by various studies. This review presents the history, characteristics of …