[HTML][HTML] Membrane-attached mammalian cytochromes P450: An overview of the membrane's effects on structure, drug binding, and interactions with redox partners
M Šrejber, V Navrátilová, M Paloncýová… - Journal of inorganic …, 2018 - Elsevier
Mammalian cytochromes P450 are an important class of enzymes involved in the
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …
[HTML][HTML] Structural foundations for explaining the physiological roles of murzymes embedded in diverse phospholipid membranes
The advent of improved structural biology protocols and bioinformatics methodologies have
provided paradigm-shifting insights on metabolic or physiological processes catalyzed by …
provided paradigm-shifting insights on metabolic or physiological processes catalyzed by …
Human cytochrome P450 enzymes 5–51 as targets of drugs and natural and environmental compounds: Mechanisms, induction, and inhibition–toxic effects and …
SP Rendic, F Peter Guengerich - Drug metabolism reviews, 2018 - Taylor & Francis
Abstract Cytochrome P450 (P450, CYP) enzymes have long been of interest due to their
roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic …
roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic …
The role of the FMN-domain of human cytochrome P450 oxidoreductase in its promiscuous interactions with structurally diverse redox partners
NADPH cytochrome P450 oxidoreductase (CPR) is the obligatory electron supplier that
sustains the activity of microsomal cytochrome P450 (CYP) enzymes. The variant nature of …
sustains the activity of microsomal cytochrome P450 (CYP) enzymes. The variant nature of …
Rare forms of congenital adrenal hyperplasia
B Gurpinar Tosun, T Guran - Clinical Endocrinology, 2023 - Wiley Online Library
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders due to
pathogenic variants in genes encoding enzymes and cofactors involved in adrenal …
pathogenic variants in genes encoding enzymes and cofactors involved in adrenal …
Computational identification and analysis of deleterious non-synonymous single nucleotide polymorphisms (nsSNPs) in the human POR gene: a structural and …
R Kumar, M Jayaraman, K Ramadas… - Journal of …, 2024 - Taylor & Francis
Cytochrome P450 oxidoreductase (POR) protein is essential for steroidogenesis, and POR
gene mutations are frequently associated with P450 Oxidoreductase Deficiency (PORD), a …
gene mutations are frequently associated with P450 Oxidoreductase Deficiency (PORD), a …
Probing the role of the hinge segment of cytochrome P450 oxidoreductase in the interaction with cytochrome P450
D Campelo, F Esteves, B Brito Palma… - International Journal of …, 2018 - mdpi.com
NADPH-cytochrome P450 reductase (CPR) is the unique redox partner of microsomal
cytochrome P450s (CYPs). CPR exists in a conformational equilibrium between open and …
cytochrome P450s (CYPs). CPR exists in a conformational equilibrium between open and …
[HTML][HTML] Loss of protein stability and function caused by P228L variation in NADPH-cytochrome P450 reductase linked to lower testosterone levels
MNR Velazquez, M Noebauer… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Cytochrome P450 oxidoreductase (POR) is the redox partner of steroid and drug-
metabolising cytochromes P450 located in the endoplasmic reticulum. Mutations in POR …
metabolising cytochromes P450 located in the endoplasmic reticulum. Mutations in POR …
The hinge segment of human NADPH-cytochrome P450 reductase in conformational switching: the critical role of ionic strength
NADPH-cytochrome P450 reductase (CPR) is a redox partner of microsomal cytochromes
P450 and is a prototype of the diflavin reductase family. CPR contains 3 distinct functional …
P450 and is a prototype of the diflavin reductase family. CPR contains 3 distinct functional …
Variability in loss of multiple enzyme activities due to the human genetic variation P284T located in the flexible hinge region of NADPH cytochrome P450 …
S Parween, MN Rojas Velazquez… - Frontiers in …, 2019 - frontiersin.org
Cytochromes P450 located in the endoplasmic reticulum require NADPH cytochrome P450
oxidoreductase (POR) for their catalytic activities. Mutations in POR cause multiple disorders …
oxidoreductase (POR) for their catalytic activities. Mutations in POR cause multiple disorders …