The proper activities of enhancers and gene promoters are essential for coordinated
transcription within a cell. Although diverse methodologies have been developed to identify …

The nuclear factor-κB (NF-κB) signaling pathway is one of the best understood immune-
related pathways thanks to almost four decades of intense research. NF-κB signaling is …

Microporous annealed particle (MAP) scaffolds are flowable, in situ crosslinked,
microporous scaffolds composed of microgel building blocks and were previously shown to …

Immunological memory is an important evolutionary trait that improves host survival upon
reinfection. Memory is a characteristic recognized within both the innate and adaptive arms …

Toll-like receptor (TLR) activation induces inflammatory responses in macrophages by
activating temporally defined transcriptional cascades. Whether concurrent changes in the …

BACKGROUND Host immune responses are classically divided into innate immune
responses, which react rapidly and nonspecifically upon encountering a pathogen, and …

Parallel single-cell sequencing protocols represent powerful methods for investigating
regulatory relationships, including epigenome-transcriptome interactions. Here, we report a …

The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …

Macrophages are crucial members of the innate immune response and important regulators.
The differentiation and activation of macrophages require the timely regulation of gene …

Innate immune cells have complex signalling pathways for sensing pathogens and initiating
innate immune responses against infection. These pathways are tightly regulated at different …