Simple Summary Tumor hypoxia remains a significant problem in the effective treatment of
most cancers. Tumor cells within hypoxic niches tend to be largely resistant to most …

The species Homo heidelbergensis is central to many discussions about recent human
evolution. For some workers, it was the last common ancestor for the subsequent species …

Abstract Notarchirico (Southern Italy) has yielded the earliest evidence of Acheulean
settlement in Italy and four older occupation levels have recently been unearthed, including …

The human settlement of Europe during Pleistocene times was sporadic and several stages
have been recognized, both from paleaoanthropological and archaeological records. If the …

Antibody-decorated liposomes can facilitate the precise delivery of chemotherapeutic drugs
to the lung by targeting a recognition factor present on the surface of lung tumor cells …

Two clearly differentiated techno-complexes can be recognised in the Iberian Peninsula
during the second half of the Middle Pleistocene: the Acheulean and the Middle Palaeolithic …

Three series of indolinone-based sulfonamides (3a–f, 6a–f and 9a–f) were in vitro evaluated
as inhibitors of the tumor-associated carbonic anhydrase (CA, EC 4.2. 1.1) isoforms hCA IX …

In the context of the Western European Acheulean Project, this study aims to characterize
Acheulean technology in Western Europe through the analysis of handaxes and cleavers …

This paper proposes a new theoretical model to explain the evolution of the genus Homo in
Europe during the Early and the Middle Pleistocene in the light of the latest human …

The introduction of biface technology in the Lower Palaeolithic arguably marked a
fundamental change in how early hominins dealt with their world. It is suggested to reflect …