Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

Mitochondrial fusion and division play important roles in the regulation of apoptosis.
Mitochondrial fusion proteins attenuate apoptosis by inhibiting release of cytochrome c from …

Since the discovery of mammalian BIK and BAD in 1995, BH3-only proteins have emerged
as key activators of apoptotic cell death in animals as diverse as the nematode …

Mitochondrial disruption is a conserved aspect of apoptosis, seen in many species from
mammals to nematodes. Despite significant conservation of other elements of the apoptotic …

Cellular conditions experienced during energy-limited states–elevated calcium, shifts in
cellular adenylate status, compromised mitochondrial membrane potential–are precisely …

The study of radiation effect in Caenorhabditis (C.) elegans has been carried out over three
decades and now allow for understanding at the molecular, cellular and individual levels …

Although mitochondria are essential organelles for long-term survival of eukaryotic cells,
recent discoveries in biochemistry and genetics have advanced our understanding of the …

Pifithrin-α, a known p53 inactivator, inhibits p53-dependant mitochondrial cell death induced
by toxins or γ-radiation. It has been found that aromatic IBT analogues of PFT-α are more …

The term “invertebrate” recalls all animal species lacking a backbone or a bony skeleton.
Although “invertebrate” is not a scientific term that encloses a taxonomic rank, this group …

Background Successful embryogenesis is a critical rate limiting step for the survival and
transmission of parasitic worms as well as pathology mediated by them. Hence, blockage of …