Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …

The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

Chromatin is dynamically reorganized when DNA replication forks are challenged. However,
the process of epigenetic reorganization and its implication for fork stability is poorly …

The recently discovered histone post-translational modification crotonylation connects
cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly …

Propagation of the chromatin landscape across cell divisions is central to epigenetic cell
memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and …

Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR)
and as the agent that is commonly used to arrest cells in the S-phase of the cycle by …

During genome replication, parental histones are recycled to newly replicated DNA with
their posttranslational modifications (PTMs). Whether sister chromatids inherit modified …

Epigenetic states defined by chromatin can be maintained through mitotic cell division.
However, it remains unknown how histone-based information is transmitted. Here we …

Following the discovery in 1998 of γ-H2AX, the first histone modification induced by DNA
damage, interest in the changes to chromatin induced by DNA damage has exploded, and a …

Nucleosome assembly following DNA replication, DNA repair and gene transcription is
critical for the maintenance of genome stability and epigenetic information. Nucleosomes …