Over the past few decades, RNA sequencing has significantly progressed, becoming a
paramount approach for transcriptome profiling. The revolution from bulk RNA sequencing …

Gliomas are complex and heterogeneous brain tumors with poor prognosis. Glioma cells
can communicate with their surroundings to create a tumor-permissive microenvironment …

Background The tRNA-derived small RNAs (tsRNAs) are produced in a nuclease-
dependent manner in responses to variety of stresses that are common in cancers. We focus …

Exosomes have shown great potential in disease diagnostics and therapeutics. However,
current isolation approaches are burdensome and suffer from low speed, yield and purity …

Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive tumors all over the
world, has a generally poor prognosis, and its progression is positively correlated with the …

Numerous studies have shown that RNA plays an important role in the occurrence and
development of diseases, and RNA-disease associations are not limited to noncoding RNAs …

Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …

As one of the most abundant and conserved RNA species, transfer RNAs (tRNAs) are well
known for their role in reading the codons on messenger RNAs and translating them into …

Despite the multiple ongoing and novel initiatives for developing brain-targeted drug
delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can …

Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and
microRNAs. They can originate from both healthy and stressed cells, and provide a …