Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Vesicular/membrane trafficking essentially regulates the compartmentalization and
abundance of proteins within the cells and contributes in many signalling pathways. This …

Exosomes are secreted membrane vesicles that share structural and biochemical
characteristics with intraluminal vesicles of multivesicular endosomes (MVEs). Exosomes …

Rab proteins constitute the largest branch of the Ras GTPase superfamily. Rabs use the
guanine nucleotide-dependent switch mechanism common to the superfamily to regulate …

Phagosome maturation is the process by which internalized particles (such as bacteria and
apoptotic cells) are trafficked into a series of increasingly acidified membrane-bound …

Small GTPases of the rab family control distinct steps of intracellular transport. The function
of their GTPase activity is not completely understood. To investigate the role of the …

▪ Abstract Pollen tubes and root hairs are highly elongated, cylindrically shaped cells whose
polarized growth permits them to explore the environment for the benefit of the entire plant …

Rab proteins are small GTP-binding proteins that form the largest family within the Ras
superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as membrane …

▪ Abstract Membrane fusion involves the merger of two phospholipid bilayers in an aqueous
environment. In artificial lipid bilayers, fusion proceeds by means of defined transition states …

Members of the Rab or ARF/Sar branches of the Ras GTPase superfamily regulate almost
every step of intracellular membrane traffic. A rapidly growing body of evidence indicates …