Progress in mathematical modeling of gastrointestinal slow wave abnormalities

P Du, S Calder, TR Angeli, S Sathar… - Frontiers in …, 2018 - frontiersin.org
Gastrointestinal (GI) motility is regulated in part by electrophysiological events called slow
waves, which are generated by the interstitial cells of Cajal (ICC). Slow waves propagate by …

Slow wave conduction patterns in the stomach: from W aller's Foundations to Current Challenges

LK Cheng - Acta Physiologica, 2015 - Wiley Online Library
This review provides an overview of our understanding of motility and slow wave
propagation in the stomach. It begins by reviewing seminal studies conducted by W alter C …

A real-time stress classification system based on arousal analysis of the nervous system by an F-state machine

R Martinez, E Irigoyen, A Arruti, JI Martín… - Computer methods and …, 2017 - Elsevier
Background and objective Detection and labelling of an increment in the human stress level
is a contribution focused principally on improving the quality of life of people. This work is …

On a coupled electro-chemomechanical model of gastric smooth muscle contraction

L Klemm, R Seydewitz, M Borsdorf, T Siebert, M Böl - Acta biomaterialia, 2020 - Elsevier
The stomach is a central organ in the gastrointestinal tract that performs a variety of
functions, in which the spatio-temporal organisation of active smooth muscle contraction in …

[HTML][HTML] Three-dimensional multi-field modelling of gastric arrhythmias and their effects on antral contractions

L Klemm, R Seydewitz, T Siebert, M Böl - Computers in Biology and …, 2023 - Elsevier
The contraction activation of smooth muscle in the stomach wall (SW) is coordinated by slow
electrical waves. The interstitial cells of Cajal (ICC), specialised pacemaker cells, initiate and …

A multiscale tridomain model for simulating bioelectric gastric pacing

S Sathar, ML Trew, G O'Grady… - IEEE Transactions on …, 2015 - ieeexplore.ieee.org
Goal: Gastric motility disorders have been associated with abnormal slow wave electrical
activity (gastric dysrhythmias). Gastric pacing is a potential therapy for gastric dysrhythmias; …

A computational model of biophysical properties of the rat stomach informed by comprehensive analysis of muscle anatomy

R Avci, JD Wickens, M Sangi… - 2022 44th Annual …, 2022 - ieeexplore.ieee.org
An anatomically based 3D computational model of the rat stomach was developed using
experimental muscle thickness measurements and muscle fiber orientations for the …

Developmental changes in postnatal murine intestinal interstitial cell of Cajal network structure and function

J Gao, S Sathar, G O'Grady, J Han… - Annals of biomedical …, 2014 - Springer
The mammalian gastrointestinal (GI) tract undergoes rapid development during early
postnatal life in order to transition from a milk to solid diet. Interstitial cells of Cajal (ICC) are …

Tissue specific simulations of interstitial cells of cajal networks using unstructured meshes

S Sathar, ML Trew, LK Cheng - 2015 37th Annual International …, 2015 - ieeexplore.ieee.org
Gastrointestinal motility is facilitated by specialized pacemaker cells called Interstitial Cells
of Cajal (ICC). ICC play a critical role in coordinating normal motility and its degradation in …

Mechanistic assessment and ablation of left ventricular assist device related ventricular tachycardia in patients with severe heart failure

F Hohendanner, M Bock, J Keznickl-Pulst… - Frontiers in …, 2023 - frontiersin.org
Aims: Left-ventricular-assist-devices (lvad) are an established treatment for patients with
severe heart failure with reduced ejection fraction (HF) and reduce mortality. However, HF …