As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

Joint diseases are one of the most common causes of morbidity and disability worldwide.
The main diseases that affect joint cartilage are osteoarthritis and rheumatoid arthritis, which …

In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and
trabecular bone form a biocomposite—referred to as the osteochondral unit—that is …

Osteoarthritis (OA), is a major cause of severe joint pain, physical disability and quality of life
impairment in the aging population across the developed and developing world. Increased …

Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

Background: Intra-articular (IA) treatment with platelet-rich plasma (PRP) for osteoarthritis
(OA) results in improved patient-reported pain and function scores. Purpose: To measure the …

Although older age is the greatest risk factor for osteoarthritis (OA), OA is not an inevitable
consequence of growing old. Radiographic changes of OA, particularly osteophytes, are …

As their name implies, matrix metalloproteinases are thought to be responsible for the
turnover and degradation of the extracellular matrix. However, matrix degradation is neither …

The prevalence of osteoarthritis (OA) increases with age such that 30% to 50% of adults
older than 65 years suffer from this condition. 1, 2 Radiographic changes of OA, in particular …

As the cellular component of articular cartilage, chondrocytes are responsible for
maintaining in a low-turnover state the unique composition and organization of the matrix …