As early as the 19th century, OIH was observed in patients receiving morphine for pain. It
was recognized that a potent analgesic such as morphine could actually result in an …

Office-based detoxification, reduction of opioid dose, opioid rotation, and the use of specific
NMDA receptor antagonists are all viable treatment options for OIH. The role of sublingual …

Objectives: We aimed to examine the published literature on basic science explaining
pronociceptive opioid actions, and apply this knowledge to clinical observation. Methods …

Opioids have become the unequivocal therapy of choice in treating many varieties of chronic
pain. With the increased prescription of opioids, some unintended consequences have …

Chronic pain patients receiving opioid drugs are at risk for opioid-induced hyperalgesia
(OIH), wherein opioid pain medication leads to a paradoxical pain state. OIH involves central …

Opioid analgesics have become a cornerstone in the treatment of moderate to severe pain,
resulting in a steady rise of opioid prescriptions. Subsequently, there has been a striking …

Preclinical studies have suggested that opioid exposure may induce a paradoxical decrease
in the nociceptive threshold, commonly referred as opioid-induced hyperalgesia (OIH) …

Patients requiring chronic opioid therapy may not respond to or tolerate the first opioid
prescribed to them, necessitating rotation to another opioid. They may also require dose …

Objective This study aims to determine the effectiveness of converting patients from high
doses of full-opioid agonists to sublingual (SL) buprenorphine. Design An observational …

Chronic pain is one of the most common complaints seen in general practitioners' offices,
and it contributes to social, emotional, physical, and economical losses. The management of …