Common functions of disordered proteins across evolutionary distant organisms

A Wallmann, C Kesten - International journal of molecular sciences, 2020 - mdpi.com
Intrinsically disordered proteins and regions typically lack a well-defined structure and thus
fall outside the scope of the classic sequence–structure–function relationship. Hence …

[HTML][HTML] Cisplatin-induced PANDAR-Chemo-EVs contribute to a more aggressive and chemoresistant ovarian cancer phenotype through the SRSF9-SIRT4/SIRT6 …

H Wang, Y Li, Y Wang, X Shang, Z Yan… - Journal of Gynecologic …, 2024 - ncbi.nlm.nih.gov
Objective We previously elucidated that long non-coding RNA Promoter of CDKN1A
Antisense DNA damage Activated RNA (PANDAR) as a p53-dependent oncogene to …

Insight into the Structural Basis for Dual Nucleic Acid—Recognition by the Scaffold Attachment Factor B2 Protein

SM Korn, J Von Ehr, K Dhamotharan, JN Tants… - International Journal of …, 2023 - mdpi.com
The family of scaffold attachment factor B (SAFB) proteins comprises three members and
was first identified as binders of the nuclear matrix/scaffold. Over the past two decades …

The molecular and functional interaction between membrane-bound organelles and membrane-less condensates

C Zhou - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
A major recent advance in cell biology is the mechanistic and kinetic understanding of
biogenesis of many membrane-less condensates. As membrane-less condensates and …

Intrinsically disordered signaling proteins: Essential hub players in the control of stress responses in Saccharomyces cerevisiae

L French-Pacheco, O Rosas-Bringas, L Segovia… - Plos one, 2022 - journals.plos.org
Cells have developed diverse mechanisms to monitor changes in their surroundings. This
allows them to establish effective responses to cope with adverse environments. Some of …

Image‐based deep learning reveals the responses of human motor neurons to stress and VCP‐related ALS

C Verzat, J Harley, R Patani… - Neuropathology and …, 2022 - Wiley Online Library
Aims Although morphological attributes of cells and their substructures are recognised
readouts of physiological or pathophysiological states, these have been relatively …

Image-based deep learning reveals the responses of human motor neurons to stress and ALS

C Verzat, J Harley, R Patani, R Luisier - bioRxiv, 2021 - biorxiv.org
Although morphological attributes of cells and their substructures are recognized readouts of
physiological or pathophysiological states, these have been relatively understudied in …