Advances in neuroscience identified addiction as a chronic brain disease with strong
genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit …

Relatively little is known about the neuropathophysiology of binge-eating disorder (BED).
Here, the evidence from neuroimaging, neurocognitive, genetics, and animal studies are …

Importance Stimulant use disorder is common, affecting between 0.3% and 1.1% of the
population, and costs more than $85 billion per year globally. There are no licensed …

This review updates the existing knowledge suggesting a role for the D3 receptor in
schizophrenia and drug addiction. The D3 receptor is expressed in brain regions controlling …

Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and
abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc) …

Drugs of abuse induce persistent remodeling of reward circuit function, a process thought to
underlie the emergence of drug craving and relapse to drug use. However, how circuit …

Repeated drug use can change dopamine (DA) function in ways that promote the
development and persistence of addiction, but in what direction? By one view, drug use …

Drug addiction has been associated with deficits in mesostriatal dopamine (DA) function, but
whether this state extends to behavioral addictions such as pathological gambling (PG) is …

Substance-use disorders are a global public health problem that arises from behavioral
misallocation between drug use and more adaptive behaviors maintained by nondrug …

Delineating common and separable neural alterations in substance use disorders (SUD) is
imperative to understand the neurobiological basis of the addictive process and to inform …