A poisson-gaussian denoising dataset with real fluorescence microscopy images

Y Zhang, Y Zhu, E Nichols, Q Wang… - Proceedings of the …, 2019 - openaccess.thecvf.com
Fluorescence microscopy has enabled a dramatic development in modern biology. Due to
its inherently weak signal, fluorescence microscopy is not only much noisier than …

Automatic segmentation of intravital fluorescence microscopy images by K-means clustering of FLIM phasors

Y Zhang, T Hato, PC Dagher, EL Nichols, CJ Smith… - Optics Letters, 2019 - opg.optica.org
Fluorescence lifetime imaging microscopy (FLIM) provides additional contrast for
fluorophores with overlapping emission spectra. The phasor approach to FLIM greatly …

Super-resolution fluorescence microscopy by stepwise optical saturation

Y Zhang, PD Nallathamby, GD Vigil… - Biomedical Optics …, 2018 - opg.optica.org
Super-resolution fluorescence microscopy is an important tool in biomedical research for its
ability to discern features smaller than the diffraction limit. However, due to its difficult …

Generalized stepwise optical saturation enables super-resolution fluorescence lifetime imaging microscopy

Y Zhang, D Benirschke, O Abdalsalam… - Biomedical Optics …, 2018 - opg.optica.org
We present a novel super-resolution fluorescence lifetime microscopy technique called
generalized stepwise optical saturation (GSOS) that generalizes and extends the concept of …

Parallelized fluorescence lifetime imaging microscopy (FLIM) based on photon reassignment

S Liu, Z Zhang, J Zheng, L Xu, C Kuang, X Liu - Optics Communications, 2018 - Elsevier
We propose a novel parallelized fluorescence lifetime imaging microscopy (FLIM) method
based on photon reassignment with a detector array and time-correlated single photon …

NLED: Neighbor linear-embedding denoising for fluorescence microscopy images

C Kirmiziay, B Aydeniz, M Turkan - 2022 Medical Technologies …, 2022 - ieeexplore.ieee.org
As noise corruption is an inevitable issue for all imaging technologies, this problem causes
serious difficulties in analyzing the biological fine-details of fluorescence microscopy …

Three-dimensional deep tissue multiphoton frequency-domain fluorescence lifetime imaging microscopy via phase multiplexing and adaptive optics

Y Zhang, IH Guldner, EL Nichols… - … Microscopy in the …, 2019 - spiedigitallibrary.org
We propose and demonstrate a novel multiphoton frequency-domain fluorescence lifetime
imaging microscopy (MPM-FD-FLIM) system that is able to generate 3D lifetime images in …

Super-resolution multiphoton frequency-domain fluorescence lifetime imaging microscopy by generalized stepwise optical saturation (GSOS)

Y Zhang, D Benirschke, O Abdalsalam… - Single Molecule …, 2019 - spiedigitallibrary.org
We present the first experimental demonstration of super-resolution multiphoton frequency-
domain (FD) fluorescence lifetime imaging microscopy (FLIM). This is obtained through a …

[PDF][PDF] Fluorescence Microscopy Denoizing via Neighbor Linear Embedding.

C Kirmiziay, B Aydeniz, M Turkan - Electrica, 2024 - electricajournal.org
One of the diculties in studying uorescence imaging of biological structures is the presence
of noise corruption. Even though hardware-and software-related technologies have …

Stepwise optical saturation microscopy: obtaining super-resolution images with conventional fluorescence microscopes

Y Zhang, D Benirschke, SS Howard - Clinical and Translational …, 2018 - opg.optica.org
We propose stepwise optical saturation (SOS) microscopy, in which two conventional
fluorescence images are linearly combined to extend the resolution by 41%. We …