Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

S Adler, D Basketter, S Creton, O Pelkonen… - Archives of …, 2011 - Springer
The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics
on the market in Europe after 2013. In that context, the European Commission invited …

Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology-a systematic review

R Klopfleisch - BMC veterinary research, 2013 - Springer
Background Histopathology has initially been and is still used to diagnose infectious,
degenerative or neoplastic diseases in humans or animals. In addition to qualitative …

Springer series in statistics

P Bickel, P Diggle, S Fienberg, U Gather, I Olkin… - Principles and Theory …, 2009 - Springer
The idea for this book came from the time the authors spent at the Statistics and Applied
Mathematical Sciences Institute (SAMSI) in Research Triangle Park in North Carolina …

Springer Series in Statistics

P Bickel, P Diggle, S Fienberg, U Gather - 2005 - Springer
Hidden Markov models—most often abbreviated to the acronym “HMMs”—are one of the
most successful statistical modelling ideas that have came up in the last forty years: the use …

Monitoring of organ formation in rat embryos after in vitro exposure to azathioprine, mercaptopurine, methotrexate or cyclosporin A

BP Schmid - Toxicology, 1984 - Elsevier
Rat embryos in the organ formation phase (days 9.5–11.5 post coitum) were cultivated in
pure rat serum in the presence of an Aroclor 1254 pretreated liver microsomal preparation …

The ECVAM International Validation Study on In Vitro Embryotoxicity Tests: Results of the Definitive Phase and Evaluation of Prediction Models

E Genschow, H Spielmann, G Scholz… - Alternatives to …, 2002 - journals.sagepub.com
From 1996 to 2000, ZEBET (Centre for Documentation and Evaluation of Alternative
Methods to Animal Experiments at the BgVV, Berlin, Germany) coordinated the European …

Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo

IWT Selderslaghs, AR Van Rompay, W De Coen… - Reproductive …, 2009 - Elsevier
We developed and optimized a screening procedure, in which zebrafish embryos were
explored as a model for the evaluation of the specific embryotoxic and teratogenic potential …

NTP center for the evaluation of risks to human reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di (2-ethylhexyl) …

R Kavlock, K Boekelheide, R Chapin… - Reproductive …, 2002 - pubmed.ncbi.nlm.nih.gov
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report
on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate NTP Center for the …

[HTML][HTML] Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies

SAB Hermsen, EJ van den Brandhof, LTM van der Ven… - Toxicology in Vitro, 2011 - Elsevier
The zebrafish embryotoxicity test (ZET) is a fast and simple method to study chemical toxicity
after exposure of the complete vertebrate embryo during embryogenesis in ovo. We …

[HTML][HTML] Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms

M Ouedraogo, T Baudoux, C Stévigny, J Nortier… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The increasing use of traditional herbal
medicines around the world requires more scientific evidence for their putative …