[HTML][HTML] Voltage sensors of a Na+ channel dissociate from the pore domain and form inter-channel dimers in the resting state
Understanding voltage-gated sodium (Nav) channels is significant since they generate
action potential. Nav channels consist of a pore domain (PD) and a voltage sensor domain …
action potential. Nav channels consist of a pore domain (PD) and a voltage sensor domain …
The structural basis of PTEN regulation by multi-site phosphorylation
Phosphatase and tensin homolog (PTEN) is a phosphatidylinositol-3, 4, 5-triphosphate
(PIP3) phospholipid phosphatase that is commonly mutated or silenced in cancer. PTEN's …
(PIP3) phospholipid phosphatase that is commonly mutated or silenced in cancer. PTEN's …
[HTML][HTML] Coupling sensor to enzyme in the voltage sensing phosphatase
Y Yu, L Zhang, B Li, Z Fu, SG Brohawn… - Nature …, 2024 - nature.com
Voltage-sensing phosphatases (VSPs) dephosphorylate phosphoinositide (PIP) signaling
lipids in response to membrane depolarization. VSPs possess an S4-containing voltage …
lipids in response to membrane depolarization. VSPs possess an S4-containing voltage …
Molecular mechanisms of coupling to voltage sensors in voltage-evoked cellular signals
Y Okamura, Y Okochi - Proceedings of the Japan Academy, Series B, 2019 - jstage.jst.go.jp
The voltage sensor domain (VSD) has long been studied as a unique domain intrinsic to
voltage-gated ion channels (VGICs). Within VGICs, the VSD is tightly coupled to the pore …
voltage-gated ion channels (VGICs). Within VGICs, the VSD is tightly coupled to the pore …
[HTML][HTML] Role of K364 next to the active site cysteine in voltage-dependent phosphatase activity of Ci-VSP
IC Paixao, N Mizutani, M Matsuda, RT Andriani… - Biophysical …, 2023 - cell.com
Voltage-sensing phosphatase (VSP) consists of the voltage sensor domain (VSD) similar to
that of voltage-gated ion channels and the cytoplasmic phosphatase region with remarkable …
that of voltage-gated ion channels and the cytoplasmic phosphatase region with remarkable …
Anionic Phospholipids Bind to and Modulate the Activity of Human TRESK Background K+ Channel
JP Giblin, I Etayo, A Castellanos, A Andres-Bilbe… - Molecular …, 2019 - Springer
The background K+ channel TRESK regulates sensory neuron excitability, and changes in
its function/expression contribute to neuronal hyperexcitability after injury/inflammation …
its function/expression contribute to neuronal hyperexcitability after injury/inflammation …
[HTML][HTML] Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase
V Rayaprolu, HM Miettinen, WD Baker… - Journal of General …, 2024 - rupress.org
The voltage-sensing domain (VSD) is a four-helix modular protein domain that converts
electrical signals into conformational changes, leading to open pores and active enzymes. In …
electrical signals into conformational changes, leading to open pores and active enzymes. In …
[HTML][HTML] Conserved Amino Acids Residing Outside the Voltage Field Can Shift the Voltage Sensitivity and Increase the Signal Speed and Size of Ciona Based GEVIs
To identify potential regions of the voltage-sensing domain that could shift the voltage
sensitivity of Ciona intestinalis based Genetically Encoded Voltage Indicators (GEVIs), we …
sensitivity of Ciona intestinalis based Genetically Encoded Voltage Indicators (GEVIs), we …
Engineering an enhanced voltage-sensing phosphatase
A Kawanabe, N Mizutani, OK Polat… - Journal of General …, 2020 - rupress.org
Voltage-sensing phosphatases (VSP) consist of a membrane-spanning voltage sensor
domain and a cytoplasmic region that has enzymatic activity toward phosphoinositides (PIs) …
domain and a cytoplasmic region that has enzymatic activity toward phosphoinositides (PIs) …
[HTML][HTML] The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase
A Kawanabe, M Hashimoto, M Nishizawa, K Nishizawa… - Elife, 2018 - elifesciences.org
Voltage-sensing phosphatases (VSP) contain a voltage sensor domain (VSD) similar to that
of voltage-gated ion channels but lack a pore-gate domain. A VSD in a VSP regulates the …
of voltage-gated ion channels but lack a pore-gate domain. A VSD in a VSP regulates the …