Oxidative dysregulation in early life stress and posttraumatic stress disorder: a comprehensive review

E Karanikas, NP Daskalakis, A Agorastos - Brain Sciences, 2021 - mdpi.com
Traumatic stress may chronically affect master homeostatic systems at the crossroads of
peripheral and central susceptibility pathways and lead to the biological embedment of …

Forgetting unwanted memories: Active forgetting and implications for the development of psychological disorders

M Costanzi, B Cianfanelli, A Santirocchi… - Journal of Personalized …, 2021 - mdpi.com
Intrusive memories are a common feature of many psychopathologies, and suppression-
induced forgetting of unwanted memories appears as a critical ability to preserve mental …

The association of PTSD symptom severity with amygdala nuclei volumes in traumatized youths

OT Ousdal, AM Milde, GS Hafstad, E Hodneland… - Translational …, 2020 - nature.com
The amygdala is a core component in neurobiological models of stress and stress-related
pathologies, including post-traumatic stress disorder (PTSD). While numerous studies have …

Stress resilience-associated behaviors following predator scent stress are accompanied by upregulated nucleus accumbens mGlu5 transcription in female Sprague …

HL Blount, J Dee, L Wu, M Schwendt… - Behavioural Brain …, 2023 - Elsevier
Despite the higher prevalence of post-traumatic stress disorder (PTSD) in women, the
majority of preclinical research has been conducted utilizing male subjects. We have found …

[HTML][HTML] Meta-analysis and open-source database for in vivo brain Magnetic Resonance spectroscopy in health and disease

AT Gudmundson, A Koo, A Virovka, AL Amirault… - Analytical …, 2023 - Elsevier
Abstract Proton (1 H) Magnetic Resonance Spectroscopy (MRS) is a non-invasive tool
capable of quantifying brain metabolite concentrations in vivo. Prioritization of …

Longitudinal trajectories of anterior cingulate glutamate and subclinical psychotic experiences in early adolescence: the impact of bullying victimization

N Okada, N Yahata, D Koshiyama, K Morita… - Molecular …, 2024 - nature.com
Previous studies reported decreased glutamate levels in the anterior cingulate cortex (ACC)
in non-treatment-resistant schizophrenia and first-episode psychosis. However, ACC …

Suicidality associated with deep brain stimulation in extrapyramidal diseases: A critical review and hypotheses on neuroanatomical and neuroimmune mechanisms

A Costanza, M Radomska, G Bondolfi… - Frontiers in integrative …, 2021 - frontiersin.org
Deep brain stimulation (DBS) is a very well-established and effective treatment for patients
with extrapyramidal diseases. Despite its generally favorable clinical efficacy, some …

Prefrontal metabolite alterations in individuals with posttraumatic stress disorder: a 7T magnetic resonance spectroscopy study

MA Reid, SE Whiteman, AA Camden… - Chronic …, 2024 - journals.sagepub.com
Background Evidence from animal and human studies suggests glutamatergic dysfunction
in posttraumatic stress disorder (PTSD). The purpose of this study was to investigate …

Signatures of exposure to childhood trauma in young adults in the structure and neurochemistry of the superior temporal gyrus

P Hepsomali, S Machon, H Barker… - Journal of …, 2023 - journals.sagepub.com
Background: Childhood trauma (CT) has been linked to increased risk for mental illness in
adulthood. Although work in experimental animals has shown that early life stressors can …

A proof-of-mechanism study to test effects of the NMDA receptor antagonist lanicemine on behavioral sensitization in individuals with symptoms of PTSD

M Lijffijt, CE Green, N Balderston, T Iqbal… - Frontiers in …, 2019 - frontiersin.org
Background: Individuals with post-traumatic stress disorder (PTSD) have a heightened
sensitivity to subsequent stressors, addictive drugs, and symptom recurrence, a form of …