It is generally accepted that fibroblast-to-myofibroblast differentiation represents a key event
during wound healing and tissue repair. The high contractile force generated by …

Integrins are crucial for the ability of cells to sense mechanical perturbations and to transmit
intracellular stress to their environment. We here review the more recently discovered role of …

The conjunctive presence of mechanical stress and active transforming growth factor β1
(TGF-β1) is essential to convert fibroblasts into contractile myofibroblasts, which cause …

Excess scar formation occurs after dermal injury as a result of abnormal wound healing.
Hypertrophic scars and keloids both represent fibrotic skin conditions which can be very …

Scarring, tightly associated with fibrosis, is a significant symptomatic clinical problem.
Interleukin 10 (IL-10) has been identified as a candidate scar-improving therapy based on …

Background The hypertrophic scar (HS) is a serious fibrotic skin condition and a major
clinical problem. Interleukin-10 (IL-10) has been identified as a prospective scar-improving …

The inflammatory process has direct effects on normal and abnormal wound healing.
Hypertrophic scar formation is an aberrant form of wound healing and is an indication of an …

Wound healing in hypertrophic scarring and keloid animal models presents significant
differences when compared with humans. A brief review is presented about hypertrophic …

Keloid formation occurs as a result of abnormal wound healing. Despite the high prevalence
of keloids in the general population, they remain one of the more challenging dermatologic …

Keloid and hypertrophic scars (HSs) are fibroproliferative diseases (FPDs) of the skin. It is
well known that stretching tension of skin, in other words mechanical force (mechanical …