Prostate cancer progression has been shown to be dependent on the development of
autonomic nerves into the tumour microenvironment. Sympathetic nerves activate …

Simple Summary Prostate cancer is one of the most frequently diagnosed cancers in men
worldwide. Perineural invasion (PNI), the movement of cancer cells along nerves, is a …

Purpose Perineural invasion (PNI) is a histologic feature that is present in as many as 84%
of patients with prostate cancer. The prognostic significance of PNI is controversial, with …

Active surveillance is the preferred strategy for very low risk, low risk, and some favorable
intermediate risk of prostate cancer. However, the current risk stratifications with initial …

Objective To estimate the prognostic value of positive surgical margins (PSM) location and
perineural invasion (PNI) for biochemical recurrence (BCR) in patients undergoing radical …

Background The pathological phenotype of perineural invasion (PNI) in squamous cell
carcinoma (ESCC) is prevalent but highly heterogeneous. Methods Postoperative …

A wide range of variables are associated with poor long-term outcomes of radical treatment
in patients with prostate cancer (PCa). Expression of the programmed death-1 ligand 1 (PD …

Multiple checkpoint mechanisms are overridden by cancer cells in order to develop into a
tumor. Neoplastic cells, while constantly changing during the course of cancer progression …

Purpose: The aim of this study was to evaluate the clinical impact of perineural invasion
(PNI) in prostate biopsy in patients submitted to radical prostatectomy and on active …

Purpose: To analyze the perioperative factors that influence the risk of biochemical
recurrence (BCR) in patients with localized PCa undergoing radical prostatectomy Materials …