Consensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …
important roles in growth and development, tissue and organ regeneration, as well as …
[HTML][HTML] Vascular tissue engineering: progress, challenges, and clinical promise
Although the clinical demand for bioengineered blood vessels continues to rise, current
options for vascular conduits remain limited. The synergistic combination of emerging …
options for vascular conduits remain limited. The synergistic combination of emerging …
Human blood vessel organoids as a model of diabetic vasculopathy
RA Wimmer, A Leopoldi, M Aichinger, N Wick… - Nature, 2019 - nature.com
The increasing prevalence of diabetes has resulted in a global epidemic. Diabetes is a
major cause of blindness, kidney failure, heart attacks, stroke and amputation of lower limbs …
major cause of blindness, kidney failure, heart attacks, stroke and amputation of lower limbs …
Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …
modeling and have unlocked new possibilities for understanding the mechanisms governing …
[HTML][HTML] Massive and reproducible production of liver buds entirely from human pluripotent stem cells
Organoid technology provides a revolutionary paradigm toward therapy but has yet to be
applied in humans, mainly because of reproducibility and scalability challenges. Here, we …
applied in humans, mainly because of reproducibility and scalability challenges. Here, we …
Bioprinted osteogenic and vasculogenic patterns for engineering 3D bone tissue
Fabricating 3D large‐scale bone tissue constructs with functional vasculature has been a
particular challenge in engineering tissues suitable for repairing large bone defects. To …
particular challenge in engineering tissues suitable for repairing large bone defects. To …
Generation of blood vessel organoids from human pluripotent stem cells
RA Wimmer, A Leopoldi, M Aichinger, D Kerjaschki… - Nature protocols, 2019 - nature.com
Blood vessels are fundamental to animal life and have critical roles in many diseases, such
as stroke, myocardial infarction and diabetes. The vasculature is formed by endothelial cells …
as stroke, myocardial infarction and diabetes. The vasculature is formed by endothelial cells …
Engineering vascularized organoid-on-a-chip models
VS Shirure, CCW Hughes… - Annual Review of …, 2021 - annualreviews.org
Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …
Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling
Human pluripotent stem cell (hPSC)-derived endothelial cells and their progenitors may
provide the means for vascularization of tissue-engineered constructs and can serve as …
provide the means for vascularization of tissue-engineered constructs and can serve as …
Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells
Human endothelial cells (ECs) and pericytes are of great interest for research on vascular
development and disease, as well as for future therapy. This protocol describes the efficient …
development and disease, as well as for future therapy. This protocol describes the efficient …