Fundamentals and methods for T‐and B‐cell epitope prediction
JL Sanchez-Trincado… - Journal of …, 2017 - Wiley Online Library
Adaptive immunity is mediated by T‐and B‐cells, which are immune cells capable of
developing pathogen‐specific memory that confers immunological protection. Memory and …
developing pathogen‐specific memory that confers immunological protection. Memory and …
T cell epitope predictions
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …
A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells
X Wang, WC Chang, CLW Wong… - Blood, The Journal …, 2011 - ashpublications.org
An unmet need in cell engineering is the availability of a single transgene encoded,
functionally inert, human polypeptide that can serve multiple purposes, including ex vivo cell …
functionally inert, human polypeptide that can serve multiple purposes, including ex vivo cell …
T-cell epitope vaccine design by immunoinformatics
A Patronov, I Doytchinova - Open biology, 2013 - royalsocietypublishing.org
Vaccination is generally considered to be the most effective method of preventing infectious
diseases. All vaccinations work by presenting a foreign antigen to the immune system in …
diseases. All vaccinations work by presenting a foreign antigen to the immune system in …
Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction
Abstract Background Reliable predictions of Cytotoxic T lymphocyte (CTL) epitopes are
essential for rational vaccine design. Most importantly, they can minimize the experimental …
essential for rational vaccine design. Most importantly, they can minimize the experimental …
NetCTLpan: pan-specific MHC class I pathway epitope predictions
Reliable predictions of immunogenic peptides are essential in rational vaccine design and
can minimize the experimental effort needed to identify epitopes. In this work, we describe a …
can minimize the experimental effort needed to identify epitopes. In this work, we describe a …
Machine learning techniques for the prediction of B-cell and T-cell epitopes as potential vaccine targets with a specific focus on SARS-CoV-2 pathogen: A review
SNH Bukhari, A Jain, E Haq, A Mehbodniya, J Webber - Pathogens, 2022 - mdpi.com
The only part of an antigen (a protein molecule found on the surface of a pathogen) that is
composed of epitopes specific to T and B cells is recognized by the human immune system …
composed of epitopes specific to T and B cells is recognized by the human immune system …
Epitope landscape in breast and colorectal cancer
The finding that individual cancers contain many mutant genes not present in normal tissues
has prompted considerable interest in the cancer epitope landscape. To further understand …
has prompted considerable interest in the cancer epitope landscape. To further understand …
Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries
Background It has been previously shown that combinatorial peptide libraries are a useful
tool to characterize the binding specificity of class I MHC molecules. Compared to other …
tool to characterize the binding specificity of class I MHC molecules. Compared to other …
An integrative approach to CTL epitope prediction: a combined algorithm integrating MHC class I binding, TAP transport efficiency, and proteasomal cleavage …
MV Larsen, C Lundegaard, K Lamberth… - European journal of …, 2005 - Wiley Online Library
Reverse immunogenetic approaches attempt to optimize the selection of candidate
epitopes, and thus minimize the experimental effort needed to identify new epitopes. When …
epitopes, and thus minimize the experimental effort needed to identify new epitopes. When …